Comparison of Juvenile Diabetics with Positive and Negative Organ Specific Antibody Titers: Evidence for Genetic Heterogeneity-Reference-Cited by-同舟云学术

Comparison of Juvenile Diabetics with Positive and Negative Organ Specific Antibody Titers: Evidence for Genetic Heterogeneity

Published:1973-01-01 Issue:1 Volume:22 Page:63-65
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Nissley S Peter¹,Drash Allan L¹,Blizzard Robert M¹,Sperling Mark¹,Childs Barton¹

Affiliation:

1. Department of Pediatrics, Johns Hopkins University School of Medicine Baltimore, Maryland, and the Department of Pediatrics, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania

Abstract

Juvenile diabetics with significant thyroid, gastric or adrenal antibody titers were compared with juvenile diabetics with negative antibody titers on the basis of various parameters of clinical and family history. Parents and siblings of juvenile diabetics with positive antibody titers have a significantly higher frequency of positive antibody titers than do parents and siblings of juvenile diabetics with negative antibody titers. This finding provides evidence for genetic heterogeneity among juvenile diabetics.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/22/1/63/346916/22-1-63.pdf

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Reflections on the history of genetic medicine at Johns Hopkins University;American Journal of Medical Genetics Part A;2021-05-06

2. Pillars Article: Islet-cell Antibodies in Diabetes Mellitus with Autoimmune Polyendocrine Deficiencies. Lancet. 1974. 304: 1279-1283;The Journal of Immunology;2017-10-23

3. Thyroid autoimmunity in children with features of both type 1 and type 2 diabetes;Pediatric Diabetes;2008-08

4. Immunogenetic heterogeneity in type I (insulin-dependent) diabetes among the Tunisian population. HLA-DR antigens and organ-specific autoantibodies (family study);Journal of Autoimmunity;1991-06

5. Are Thyrogastric Autoantibodies Associated with an Increased Susceptibility to Developing Type 1 (Insulin-Dependent) Diabetes? A Study in Identical Twins;Autoimmunity;1990-01