Evaluation of the Role of Exogenous Insulin on Phasic Insulin Secretion

Author:

Grodsky Gerold M1,Fanska Rudy1,Schmid Florence G1

Affiliation:

1. Metabolic Research Unit and Department of Biochemistry and Biophysics, University of California San Francisco, California 94122

Abstract

The possibility that insulin-induced feedback inhibition was responsible for the phasic release of insulin during continuous stimulation was investigated in the in vitro perfused rat pancreas. Continuous perfusion with selected concentrations of glucose (110 mg./100 ml.) ortolbutamide (300 μg./ml.) produced the characteristic initial rise and fall of insulin secretion; there was no rebound to high secretion rates during the later periods of stimulation with either agent. Rat insulin, perfused in a variety of patterns to simulate both early and steady state levels of endogenous insulin secretion, neither obliterated nor significantly affected the initial spike of endogenous insulin release elicited by either glucose or tolbutamide. There was no evidence of dampened oscillation or delayed inhibition by exogenous insulin. Results indicate insulin-induced feedback inhibition is not responsible for phasic insulin secretion; the previoussuggestions that this phenomenon reflects a substrate-induced feedback inhibition or a threshold-sensitive packet storage system are viable possibilities.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Cited by 28 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3