Effects of a New Oral Hypoglycemic Agent on Glucose and Insulin after Oral Glucose Loading: A Controlled Study

Abstract

l-(2-pyrimidinyl)-4-imino-l, 4-dihydropyridine hydrochloride is a new compound which after oral administration of a single dose of 400 mg. causes significant reductions of hyperglycemia and insulin response in human subjects after an oral glucose load. These results were obtained when compared to a single dose of 200 mg. of phenformin hydrochloride or placebo in a double-blind completely randomized crossover study with placebo and phenformin. Both drugs also produced a significant fall in the fasting serum glucose value before the oral glucose load without any significant effect on serum insulin values. Both drugs produced similar adverse symptoms in the six healthy subjects who participated in the study.