Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?-Reference-Cited by-同舟云学术

Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?

Published:2012-07-17 Issue:8 Volume:61 Page:1907-1914
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Dunne Jessica L.¹,Overbergh Lut²,Purcell Anthony W.³⁴,Mathieu Chantal²

Affiliation:

1. Juvenile Diabetes Research Foundation, New York, New York

2. Laboratory of Experimental Medicine and Endocrinology (LEGENDO), Catholic University Leuven, Leuven, Belgium

3. Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Victoria, Australia

4. Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia

Abstract

The overall role of modification of β-cell antigens in type 1 diabetes has not been elucidated and was the focus of a recent workshop on posttranslational modification of proteins in type 1 diabetes. The prevailing opinion of the workshop attendees was that novel insights into the mechanism of loss of immune tolerance might be gained and that novel diagnostic and therapeutic approaches could be developed for type 1 diabetes if protein modifications were shown to play a critical role in the disease.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/61/8/1907/564359/1907.pdf

Reference43 articles.

1. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes;Eizirik;Nat Rev Endocrinol,2009

2. ER stress in pancreatic beta cells: the thin red line between adaptation and failure;Eizirik;Sci Signal,2010

3. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease;Hotamisligil;Cell,2010

4. Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells;Ortis;Diabetes,2010

5. Novel insights into the global proteome responses of insulin-producing INS-1E cells to different degrees of endoplasmic reticulum stress;D’Hertog;J Proteome Res,2010

Cited by 40 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nonenzymatic Posttranslational Modifications and Peptide Cleavages Observed in Peptide Epimers;Journal of the American Society for Mass Spectrometry;2023-04-27

2. Epigenetics and precision medicine in diabetes and obesity prevention and management;Epigenetics in Precision Medicine;2022

3. Glycation of HDL blunts its anti-inflammatory and cholesterol efflux capacities in vitro, but has no effect in poorly controlled type 1 diabetes subjects;Journal of Diabetes and its Complications;2020-12

4. Modeling different types of diabetes using human pluripotent stem cells;Cellular and Molecular Life Sciences;2020-11-26

5. Inducible de novo expression of neoantigens in tumor cells and mice;Nature Biotechnology;2020-07-27