Affiliation:
1. Merck Sharp & Dohme Research Laboratories, Division of Merck & Co., Inc. Rahway, New Jersey
Abstract
Light and electron microscopic examination of organs of rats rendered hyperglycemic with streptozotocin revealed the following: (1) rapid degranulation of beta cells without necrosis; (2) development of cataracts in four months after injection of 65 mg. per kilogram of the drug; (3) accumulation of glycogen in the proximal convoluted tubules of the kidney after 65 mg. per kilogram; (4) lesions in the exocrine cells of the pancreas after 100 mg. per kilogram; and (5) persistence of small, possibly secretory, granules in the Golgi zone of beta cells in diabetic rats. The significance of these findings is discussed.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
242 articles.
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