Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes-Reference-Cited by-同舟云学术

Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes

Published:2009-03-05 Issue:6 Volume:32 Page:1046-1048
ISSN:0149-5992
Container-title:Diabetes Care
language:en
Short-container-title:

Author:

Jensen Dorte M.¹,Korsholm Lars²,Ovesen Per³,Beck-Nielsen Henning¹,Moelsted-Pedersen Lars⁴,Westergaard Jes G.⁵,Moeller Margrethe⁶,Damm Peter⁷

Affiliation:

1. Department of Endocrinology, Odense University Hospital, University of Southern Denmark, Odense, Denmark;

2. Institute of Statistics and Demographics, University of Southern Denmark, Odense, Denmark;

3. Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Denmark;

4. Department of Obstetrics and Gynecology, Copenhagen County Hospital, University of Copenhagen, Copenhagen, Denmark;

5. Department of Obstetrics and Gynecology, Odense University Hospital, Odense, Denmark;

6. Department of Obstetrics and Gynecology, Aalborg University Hospital, Aalborg, Denmark;

7. Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Abstract

OBJECTIVE To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://diabetesjournals.org/care/article-pdf/32/6/1046/601593/zdc00609001046.pdf

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