Single Nucleotide Polymorphisms in the Peroxisome Proliferator–Activated Receptor δ Gene Are Associated With Skeletal Muscle Glucose Uptake-Reference-Cited by-同舟云学术

Single Nucleotide Polymorphisms in the Peroxisome Proliferator–Activated Receptor δ Gene Are Associated With Skeletal Muscle Glucose Uptake

Published:2005-12-01 Issue:12 Volume:54 Page:3587-3591
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Vänttinen Markku¹,Nuutila Pirjo²³,Kuulasmaa Teemu¹,Pihlajamäki Jussi¹,Hällsten Kirsti²,Virtanen Kirsi A.²,Lautamäki Riikka²,Peltoniemi Pauliina²,Takala Teemu²³,Viljanen Antti P.M.²,Knuuti Juhani²,Laakso Markku¹

Affiliation:

1. Department of Medicine, University of Kuopio, Kuopio, Finland

2. Positron Emission Tomography Centre, University of Turku, Turku, Finland

3. Department of Medicine, University of Turku, Turku, Finland

Abstract

The peroxisome proliferator–activated receptors (PPARs) belong to a superfamily of nuclear receptors. It includes PPAR-δ, a key regulator of fatty acid oxidation and energy uncoupling, universally expressed in different tissues. The PPAR-δ gene (PPARD) maps to 6p21.2-p21.1 and has 11 exons and spans 35 kbp. We investigated the effects of single nucleotide polymorphisms (SNPs) of PPARD on whole-body, skeletal muscle, and subcutaneous adipose tissue glucose uptake in 129 healthy individuals using the hyperinsulinemic-euglycemic clamp technique combined with fluorine-18–labeled fluorodeoxyglucose ([18F]FDG) and positron emission tomography (PET). Three of six SNPs of PPARD and their haplogenotypes were significantly associated with whole-body insulin sensitivity. [18F]FDG-PET scanning indicated that SNPs of PPARD primarily affected insulin sensitivity by modifying glucose uptake in skeletal muscle but not in adipose tissue. Our results give evidence that SNPs of PPARD regulate insulin sensitivity particularly in skeletal muscle.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/54/12/3587/379574/zdb01205003587.pdf

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