Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener
Author:
Affiliation:
1. Department of Pharmacology, Novo Nordisk A/S, Måløv, Denmark
2. Hagedorn Research Institute, Gentofte, Denmark
3. Department of Medicinal Chemistry, Novo Nordisk A/S, Måløv, Denmark
Abstract
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
https://journals.org/diabetes/diabetes/article-pdf/53/4/1089/652908/zdb00404001089.pdf
Reference23 articles.
1. Rossetti L, Giaccari A, DeFronzo RA: Glucose toxicity. Diabetes Care 13:610–630,1990
2. Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY: Glucose-induced β-cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851–860,2002
3. Agner T, Damm P, Binder C: Remission in IDDM: prospective study of basal C-peptide and insulin dose in 268 consecutive patients. Diabetes Care 10:164–169,1987
4. Henquin JC, Meissner HP: Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells. Biochem Pharmacol 31:1407–1415,1982
5. Kullin M, Li Z, Hansen JB, Bjork E, Sandler S, Karlsson FA: K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin. Diabetes 49:1131–1136,2000
Cited by 31 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Role of cytosolic and endoplasmic reticulum Ca2+ in pancreatic beta-cells: pros and cons;Pflügers Archiv - European Journal of Physiology;2023-11-09
2. Protective effects of acarbose against insulitis in multiple low-dose streptozotocin-induced diabetic mice;Life Sciences;2020-12
3. Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063;Journal of Pharmacology and Experimental Therapeutics;2019-06-14
4. Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice;Diabetologia;2015-06-06
5. The Expression of the Beta Cell-Derived Autoimmune Ligand for the Killer Receptor Nkp46 Is Attenuated in Type 2 Diabetes;PLoS ONE;2013-08-29
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3