The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4+CD25+ Regulatory T-Cells-Reference-Cited by-同舟云学术

The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4+CD25+ Regulatory T-Cells

Published:2006-01-01 Issue:1 Volume:55 Page:186-192
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Rogner Ute Christine¹,Lepault Françoise²,Gagnerault Marie-Claude²,Vallois David²,Morin Joëlle²,Avner Philip¹,Boitard Christian²

Affiliation:

1. Unité de Génétique Moléculaire Murine, Centre National de Recherche (CNRS) Unité de Recherche Associée (URA) 2578, Institut Pasteur, Paris, France

2. Hôpital Cochin St. Vincent de Paul, Paris, France

Abstract

The genetic locus Idd6 confers susceptibility to the spontaneous development of type 1 diabetes in the NOD mouse. Our studies on disease resistance of the congenic mouse strain NOD.C3H 6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and suggest that a major mechanism by which the Idd6 locus modifies diabetes development is via modulation of regulatory T-cell activities. Our transfer experiments using total splenocytes and purified T-cells demonstrated that the locus specifically controls the efficiency of disease protection mediated by the regulatory CD4+CD25+ T-cell subset. Our data also implicate the Idd6 locus in controlling the balance between infiltrating lymphocytes and antigen-presenting cells within the pancreatic islet.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/55/1/186/381363/zdb00106000186.pdf

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