The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome-Reference-Cited by-同舟云学术

The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome

Published:2003-01-01 Issue:1 Volume:52 Page:205-208
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Brook Frances A.¹,Evans Edward P.¹,Lord Christopher J.²,Lyons Paul A.²,Rainbow Daniel B.²,Howlett Sarah K.²,Wicker Linda S.²,Todd John A.²,Gardner Richard L.¹

Affiliation:

1. Department of Zoology, University of Oxford, Oxford, U.K.

2. JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.

Abstract

It would be extremely advantageous to the analysis of disease mechanisms in the spontaneous mouse model of type 1 diabetes, the nonobese diabetic (NOD) strain, if genes in this strain could be modified in vivo using embryonic stem (ES) cells and homologous recombination. However, a NOD ES cell line with adequate germline transmission has not yet been reported. We report the development of highly germline-competent ES cell lines from the F1 hybrid of NOD and 129 for use in NOD gene targeting. Consequently, we developed ES cell lines derived from (NOD × 129)F1 × 129 backcross 1 mice, which were intercrossed to select for homozygosity of particular regions of NOD genome known to contain disease loci.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/52/1/205/662774/db0103000205.pdf

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