Organization of the Human GLUT2 (Pancreatic β-Cell and Hepatocyte) Glucose Transporter Gene

Author:

Takeda Jun1,Kayano Toshiaki1,Fukomoto Hirofumi1,Bell Graeme I1

Affiliation:

1. Howard Hughes Medical Institute and the Departments of Biochemistry and Molecular Biology, and Medicine, The University of Chicago Chicago, Illinois

Abstract

The gene encoding the predominant facilitative glucose transporter expressed in pancreatic β-cells and hepatocytes, termed GLUT2, has been cloned and characterized. The human GLUT2 gene is composed of 11 exons spanning ∼30 kilobases. The sequence of the promoter region and all exons and adjacent intron regions has been determined and deposited in the GenBank database. Two highly polymorphic simple tandem repeat DNA polymorphisms useful for linkage studies were localized in introns 1 and 4a. In addition, a 168-base pair insertion/deletion polymorphism was identified in intron 3. The characterization of the human GLUT2 gene will facilitate studies of its role in the development of diabetes mellitus.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

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