Inhibition of Insulin Secretion by Aryl-substituted Secondary Aminoethanols

Abstract

The administration of glucose, tolbutamide, ACTH, and glucagon to mice resulted in increase of plasma insulin levels. These increases were all inhibited by the prior administration of aryl-substituted secondary aminoethanols (ASAE). Cyclic 3′,5′ AMP resulted in increased levels of plasma insulin in intact mice, and this stimulatory effect was also inhibited by the aryl-substituted secondary aminoethanols. The locus of the inhibitory effect of these compounds on insulin secretion is discussed.