Evaluation of a Fourth-Generation Subcutaneous Real-Time Continuous Glucose Monitor (CGM) in Individuals With Diabetes on Peritoneal Dialysis

Author:

Ng Jack K.C.1,Ling James1,Luk Andrea O.Y.123,Lau Eric S.H.1,Ma Ronald C.W.134,Li Philip K.T.1,Szeto Cheuk Chun14,Chan Juliana C.N.134,Chow Elaine12ORCID

Affiliation:

1. 1Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR

2. 2Phase 1 Clinical Trial Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR

3. 3Hong Kong Institute of Diabetes and Obesity,Hong Kong SAR

4. 4Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR

Abstract

OBJECTIVE To evaluate the performance of a real-time continuous glucose monitor (CGM) in individuals with diabetes on peritoneal dialysis (PD). RESEARCH DESIGN AND METHODS Thirty participants with type 2 diabetes on continuous ambulatory PD wore a Guardian Sensor 3 on the upper arm paired with Guardian Connect for 14 days. We compared CGM readings against Yellow Springs Instrument (YSI) venous glucose during an 8-h in-clinic session with glucose challenge. RESULTS The mean absolute relative difference (MARD) was 10.4% (95% CI 9.6, 11.7) from 941 CGM-YSI matched pairs; 81.3% of readings were within %15/15 of YSI values in the full glycemic range. Consensus error grid analysis showed 99.9% of sensor values in zones A and B. There were no correlations between pH, uremia, hydration status, and MARD. CONCLUSIONS We showed satisfactory performance of a real-time CGM sensor in PD patients with diabetes, supporting future use to facilitate treatment decisions.

Funder

Health and Medical Research Fund Commisionned Program for Phase 1 Clinical Trial Centre

Medtronic External Research Program

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

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