1. 1Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR
2. 2Phase 1 Clinical Trial Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR
3. 3Hong Kong Institute of Diabetes and Obesity,Hong Kong SAR
4. 4Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR