Intensive Lifestyle Intervention for Remission of Early Type 2 Diabetes in Primary Care in Australia: DiRECT-Aus

Author:

Hocking Samantha L.123ORCID,Markovic Tania P.123,Lee Crystal M.Y.4,Picone Tegan J.12,Gudorf Kate E.5,Colagiuri Stephen12

Affiliation:

1. 1Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia

2. 2Charles Perkins Centre, University of Sydney, Sydney, Australia

3. 3Metabolism and Obesity Service, Royal Prince Alfred Hospital, Sydney, Australia

4. 4School of Population Health, Curtin University, Perth, Australia

5. 5Diabetes Australia, Canberra, Australia

Abstract

OBJECTIVE We aimed to assess whether remission of type 2 diabetes (T2D) could be achieved with a low-energy total diet replacement (TDR) in an Australian primary care setting. RESEARCH DESIGN AND METHODS Individuals aged 20–65 years with T2D duration up to 6 years, BMI >27.0 kg/m2, and not treated with insulin were prescribed a 13-week low-energy TDR (Optifast; Nestlé Health Science) followed by 8-week structured food reintroduction and 31-week supported weight maintenance. The primary outcome was T2D remission at 12 months. RESULTS A total of 155 participants comprised the intention-to-treat population. At 12 months, T2D remission was achieved in 86 (56%) participants, with a mean adjusted weight loss of 8.1% (95% CI 7.2–9.1). Two serious adverse events requiring hospitalization related to the study intervention were reported. CONCLUSIONS At 12 months T2D remission was achieved for one in two Australian adults in a primary care setting.

Funder

South Western Sydney Primary Health Network

Healthy North Coast

Diabetes Australia

Western Sydney Primary Health Network

Western NSW Primary Health Network

Nestle Health Science

Sydney North Health Network

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

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