Cognitive Function in Children and Subsequent Type 2 Diabetes

Author:

Olsson Gunilla M.12,Hulting Anna-Lena3,Montgomery Scott M.456

Affiliation:

1. Neuroscience, Uppsala University, Uppsala, Sweden

2. Public Health, Örebro University, Örebro, Sweden

3. Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden

4. Clinical Epidemiology Unit, Karolinska University Hospital, Stockholm

5. Clinical Research Centre, Örebro University Hospital, Örebro, Sweden

6. Primary Care and Social Medicine, Imperial College, London, U.K

Abstract

OBJECTIVE—To assess whether a diagnosis of type 2 diabetes by age 42 years is associated with prior cognitive deficits in childhood. RESEARCH DESIGN AND METHODS—Logistic regression estimated type 2 diabetes risk among 9,113 members of the 1958 British birth cohort of the National Child Development Study (NCDS). Associations with type 2 diabetes were estimated for general ability and reading comprehension assessments at age 11 years, modeled using SD units. Adjustment was for markers of early-life exposures, social and material family characteristics, sex, and disability, with further adjustment for BMI at age 7 years. RESULTS—Adjusted odds ratios (95% CIs) for type 2 diabetes (n = 69) are 0.67 (0.51–0.87) for general ability and 0.58 (0.44–0.77) for reading comprehension. Neither additional adjustment for BMI, nor limiting the definition of type 2 diabetes to onset after age 33 years altered the associations substantially. CONCLUSIONS—Impaired cognitive function may precede clinical onset of type 2 diabetes.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

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