SGLT2 Inhibitors Produce Cardiorenal Benefits by Promoting Adaptive Cellular Reprogramming to Induce a State of Fasting Mimicry: A Paradigm Shift in Understanding Their Mechanism of Action
Author:
Affiliation:
1. Baylor Scott & White Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX
2. Imperial College, London, U.K.
Publisher
American Diabetes Association
Subject
Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
https://diabetesjournals.org/care/article-pdf/43/3/508/530727/dci190074.pdf
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3. Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction: the DEFINE-HF trial;Nassif;Circulation,2019
4. CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis;Ferrannini;Diabetes Care,2016
5. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis;Mudaliar;Diabetes Care,2016
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