Blood Pressure, Insulin, and C-Peplide Levels in San Luis Valley, Colorado

Author:

Every Nathan R1,Boyko Edward J1,Keane Ellen M1,Marshall Julie A1,Rewers Marian1,Hamman Richard F1

Affiliation:

1. Northwest Health Services Research and Development Field Program and Medical Service, VA Medical Center Seattle Department of Medicine, University of Washington Seattle, Washington Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine Denver, Colorado

Abstract

OBJECTIVE To explore the associations between blood pressure and both fasting insulin and C-pep tide levels. RESEARCH DESIGN AND METHODS A cross-sectional analysis was conducted of 895 normoglycemic members of a bi-ethnic community in Colorado who were selected from a control group recruited for a geographically based study of diabetes mellitus prevalence and risk factors. All subjects included in this study had normal glucose tolerance as judged by a 75-g oral glucose tolerance test interpreted using World Health Organization criteria. None of the subjects were taking antihypertensive medication. Multiple linear regression analysis was used to examine relationships between fasting insulin and C-peptide levels and blood pressure. RESULTS Among all subjects, diastolic blood pressure was found to significantly increase with increasing levels of both hormones (insulin coefficient = 0.197, P = 0.013; C-peptide coefficient = 0.0436, P = 0.004), whereas systolic blood pressure was significantly related to fasting C-peptide level (coefficient = 0.0295, P = 0.050). These relationships were similar in magnitude for both Hispanic and non-Hispanic white subjects, but were diminished among women and subjects with a higher body mass index. CONCLUSIONS Higher fasting insulin and C-peptide levels are associated with higher blood pressure, but these relationships are modified by sex and degree of obesity.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

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