Heterophile Antibodies Masquerade as Interferon-α in Subjects With New-Onset Type 1 Diabetes
Author:
Affiliation:
1. From the Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado.
Publisher
American Diabetes Association
Subject
Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
https://diabetesjournals.org/care/article-pdf/27/5/1205/565706/zdc00504001205.pdf
Reference5 articles.
1. Devendra D, Eisenbarth GS: Interferon alpha: a potential link in the pathogenesis of viral induced diabetes and autoimmunity. Clin Immunol. In press
2. Chehadeh W, Weill J, Vantyghem MC, Alm G, Lefebvre J, Wattre P, Hober D: Increased level of interferon-alpha in blood of patients with insulin-dependent diabetes mellitus: relationship with coxsackievirus B infection. J Infect Dis 181:1929–1939, 2000
3. Hober D, Chehadeh W, Weill J, Hober C, Vantyghem MC, Gronnier P, Wattre P: Circulating and cell-bound antibodies increase coxsackievirus B4-induced production of IFN-alpha by peripheral blood mononuclear cells from patients with type 1 diabetes. J Gen Virol 83:2169–2176, 2002
4. Jabs WJ, Hennig C, Zawatzky R, Kirchner H: Failure to detect antiviral activity in serum and plasma of healthy individuals displaying high activity in ELISA for IFN-alpha and IFN-beta. Interferon Cytokine Res 19:463–469, 1999
5. Hennig C, Rink L, Fagin U, Jabs WJ, Kirchner H: The influence of naturally occurring heterophile anti-immunoglobulin antibodies on direct measurement of serum proteins using sandwich ELISAs. J Immunol Methods 235:71–80, 2000
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