Plasma Adiponectin and Endogenous Glucose Production in Humans

Author:

Stefan Norbert12,Stumvoll Michael12,Vozarova Barbora1,Weyer Christian1,Funahashi Tohru3,Matsuzawa Yuji3,Bogardus Clifton1,Tataranni P. Antonio1

Affiliation:

1. Clinical Diabetes and Nutrition Section, Department of Health and Human Services, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona

2. Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, Tubingen, Germany

3. Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan

Abstract

OBJECTIVE—High plasma adiponectin is associated with reduced risk of type 2 diabetes, probably a consequence of its insulin-sensitizing properties. In vivo data in rodents suggest that the insulin-sensitization responsible for improvement of glycemia occurs in muscle and liver. Whereas associations of plasma adiponectin with muscle insulin sensitivity in humans have been examined, this has not been done for the liver. RESEARCH DESIGN AND METHODS—We therefore analyzed the relationship between fasting plasma adiponectin and basal endogenous glucose production [EGP]-basal) and insulin-suppressed EGP (EGP-insulin, isotope dilution technique) in 143 Pima Indians (94 with normal glucose tolerance, 36 with impaired glucose tolerance, and 16 with type 2 diabetes). RESULTS—Fasting plasma adiponectin concentrations were negatively correlated with EGP-basal and EGP-insulin before (P = 0.006 and P < 0.0001, respectively) as well as after adjustment for age, sex, percent body fat, and insulin-stimulated whole-body glucose uptake (P = 0.007 and P = 0.0005, respectively). CONCLUSIONS—These findings are compatible with the hypothesis that adiponectin increases hepatic insulin sensitivity. Consistent with data in animals, adiponectin may have generalized insulin-sensitizing effects in humans.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

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