The HLA System in Congenital Rubella Patients With and Without Diabetes-Reference-Cited by-同舟云学术

The HLA System in Congenital Rubella Patients With and Without Diabetes

Published:1982-12-01 Issue:12 Volume:31 Page:1088-1091
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Rubinstein P¹,Walker M E¹,Fedun B²,Win M E³,Cooper L Z²,Ginsberg-Fellner F³

Affiliation:

1. Department of Immunogenetics, The Lindsley F. Kimball Research Institute New York, New York

2. Department of Pediatrics, St. Luke's-Roosevelt Hospital New York, New York

3. Department of Pediatrics, Mount Sinai School of Medicine (CUNY) New York, New York

Abstract

The HLA antigens of 173 patients with the congenital rubella syndrome (CR) are reported. Twenty-one of these patients are also clinically diabetic, and among them the frequencies of the HLA antigens DR2 and DR3 are significantly lower and higher, respectively, than in CR patients without diabetes or in controls. These data suggest that the genes that control susceptibility to type I or insulin-dependent diabetes mel-litus are necessary for the development of glucose intolerance in CR patients.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/31/12/1088/352117/31-12-1088.pdf

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