Affiliation:
1. Human Metabolism Research Centre, University of Newcastle-upon-Tyne Newcastle-upon-Tyne, United Kingdom
Abstract
In eight healthy subjects, skin temperature at the injection site was raised from mean ± SD 31.7 ± 0.5 to 40.8 ± 0.9°C 180 min after injection of 0.25 U/kg isophane (NPH; Human Insulatard) insulin and maintained for 180 min. On the control day, skin temperature was kept constant. On warming of the injection site, serum insulin concentration rose from mean ±SE 14.4 ± 2.5 to 17.7 ± 3.1 mU/L after 40 min (P < .01) but did not change on the control day over the same period. The change in insulin concentration from the prewarming hour was higher on the warming day than control day in the 1st h (123 ± 8 vs. 93 ± 7%, P < .01), 2nd h (115 ± 14 vs. 83 ± 9%, P < .05), and 3rd h (113 ± 17 vs. 80 ± 10%, P < .05) of warming, providing evidence for both early increased absorption of the free-insulin pool surrounding the protamine-insulin complexes and continuing increased dissociation of the complexes.
Publisher
American Diabetes Association
Subject
Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
17 articles.
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