Affiliation:
1. Department of Internal Medicine, University Hospital Utrecht, The Netherlands
Abstract
OBJECTIVE
To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk.
RESEARCH DESIGN AND METHODS
The study had a double-blind, cross-over design. Insulin sensitivity was measured with the euglycemic hyperinsulinemic glucose clamp technique at two different insulin infusion rates: 0.05 (clamp 1) and 0.10 U.kg−1 · h−1 (clamp 2).
RESULTS
Subanalysis of the glucose infusion rate under steady-state conditions in the last 30 min of clamp 2 yielded a glucose infusion rate of 5.36 and 3.87 mmol.kg−1.min−1 after benfluorex and placebo, respectively (P = 0.018).
CONCLUSIONS
Benfluorex increases insulin sensitivity in obese type II diabetic patients.
Publisher
American Diabetes Association
Subject
Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
20 articles.
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