Affiliation:
1. University of Bielefeld, School of Public Health, Bielefeld, Germany
2. Department of Biometrics and Epidemiology, German Diabetes Research Institute at Heinrich Heine University
3. Department of Metabolic Diseases and Nutrition, (World Health Organization Collaborating Center for Diabetes), Heinrich Heine University, Düsseldorf, Germany
Abstract
OBJECTIVE—A reduction of diabetes-related amputations by at least one-half within 5 years was declared a primary objective for Europe (St. Vincent Declaration, 1989). We collected data about incidence rates of amputations in one German city (Leverkusen, with a population of ∼160,000 inhabitants) between 1990 and 1998 to ascertain a potential change in rates of incidence.
RESEARCH DESIGN AND METHODS—From all three hospitals in Leverkusen, we obtained complete lists of lower-limb amputations. From each patient record, diabetic status was determined. Only the first observed amputation was counted for the analysis. We estimated incidence rates of amputations in the entire population, the diabetic population, and the nondiabetic population. To test for time trend, we fitted Poisson regression models, adjusting for age and sex.
RESULTS—During the defined period (the years 1990, 1991, and 1994–1998), 339 patients (all residents of Leverkusen) without previous amputations had nontraumatic lower-limb amputations. Of all subjects, 46% were female. Moreover, 76% of the subjects were known to have diabetes. Mean age was 71.3 years. Incidence rates in the diabetic population (standardized to the estimated German diabetic population, per 100,000 person-years) were as follows: 1990, 549; 1991, 356; 1994, 544; 1995, 386; 1996, 426; 1997, 433; and 1998, 463. The Poisson models showed no significant change of incident amputations over time in the diabetic population or in the nondiabetic population.
CONCLUSIONS—Beyond random variation, no change of incidence rates could be observed over the past 9 years. More specific interventions are needed to achieve a substantial reduction of diabetes-related amputations.
Publisher
American Diabetes Association
Subject
Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine
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