Vasoactive Intestinal Polypeptide-like Immunoreactive Nerves in Diabetic Penis: A Comparison Between Streptozotocin-treated Rats and Man-Reference-Cited by-同舟云学术

Vasoactive Intestinal Polypeptide-like Immunoreactive Nerves in Diabetic Penis: A Comparison Between Streptozotocin-treated Rats and Man

Published:1983-11-01 Issue:11 Volume:32 Page:1075-1077
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Crowe R¹,Lincoln J¹,Blacklay P F²,Pryor J P³,Lumley J S P²,Burnstock G¹

Affiliation:

1. Department of Anatomy and Embryology and the Centre for Neuroscience, University College London West Smithfield

2. Department of Surgery, St. Bartholomew's Hospital West Smithfield

3. Institute of Urology, The Shaftesbury Hospital London, United Kingdom

Abstract

Vasoactive intestinal polypeptide (VIP) has been demonstrated by immunofluorescence histochermistry in nerves in human and rat penile tissue. A reduction in VIP-like immunoreactivity in nerves was revealed in tissue from streptozotocin-diabetic rats and a human diabetic with impotence. These results suggest that an impairment in the VIP-ergic innervation in penile tissue may be an important factor in the development of impotence in diabetes. They also support the view that the streptozotocin-treated rat is a useful experimental model for diabetic autonomie neuropathy.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/32/11/1075/352289/32-11-1075.pdf

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