SGLT-2 Inhibitors: A New Mechanism for Glycemic Control-Reference-Cited by-同舟云学术

SGLT-2 Inhibitors: A New Mechanism for Glycemic Control

Published:2014-01-01 Issue:1 Volume:32 Page:4-11
ISSN:0891-8929
Container-title:Clinical Diabetes
language:en
Short-container-title:

Author:

Chao Edward C.

Abstract

IN BRIEF Glucosuria, the presence of glucose in the urine, has long been regarded as a consequence of uncontrolled diabetes. However, glucose excretion can be induced by blocking the activity of the renal sodium-glucose cotransporter 2 (SGLT-2). This mechanism corrects hyperglycemia independently of insulin. This article provides an overview of the paradigm shift that triggered the development of the SGLT-2 inhibitor class of agents and summarizes the available evidence from clinical studies to date.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://diabetesjournals.org/clinical/article-pdf/32/1/4/499962/4.pdf

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