Self-Reported Gastrointestinal Symptoms in Type 2 Diabetes Improve With an Intensive Lifestyle Intervention: Results From the Action for Health in Diabetes (Look AHEAD) Clinical Trial-Reference-Cited by-同舟云学术

Self-Reported Gastrointestinal Symptoms in Type 2 Diabetes Improve With an Intensive Lifestyle Intervention: Results From the Action for Health in Diabetes (Look AHEAD) Clinical Trial

Published:2015-10-01 Issue:4 Volume:33 Page:181-188
ISSN:0891-8929
Container-title:Clinical Diabetes
language:en
Short-container-title:

Author:

Neiberg Rebecca H.¹,Rejeski Jared J.¹,Applegate William B.¹,Clark Jeanne M.²,Knowler William C.³,Bray George A.⁴,Espeland Mark A.¹,Cheskin Lawrence J.²⁵

Affiliation:

1. Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC

2. Departments of Medicine and Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD

3. Diabetes Epidemiology and Clinical Research Section, National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ

4. Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA

5. Department of Health, Behavior & Society, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD

Abstract

In Brief This article reports on an investigation of whether an intensive lifestyle intervention (ILI) would reduce gastrointestinal symptoms over 4 years of follow-up for participants in the Action for Health in Diabetes (Look AHEAD) trial compared to a diabetes support and education (DSE) group. Look AHEAD is a randomized, multicenter trial comparing overweight and obese adults with type 2 diabetes treated with ILI versus DSE. ILI, and weight loss in general, had beneficial effects on gastrointestinal (GI) symptoms, with some variability in the strength of the effect depending on the specific symptom and time course. Potential modifiers were analyzed, yet ILI retained an association with improvement in GI symptoms.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://diabetesjournals.org/clinical/article-pdf/33/4/181/500534/181.pdf

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