Affiliation:
1. Departments of Pediatrics and Genetics and the Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine Bronx, New York
Abstract
Studies have been carried out on activities of lysosomal β-N-acetylhexosaminidase (hex), β-galactosidase (β-gal), α-glucosidase (α-glu), and acid phosphatase (AP) in serum and urine from patients with juvenile diabetes and matched controls. There is a large increase in blood and urinary hex activity (the former presenting three distinct patterns of abnormality), a moderate increase in urinary β-gal, and a small increase in urinary α-glu activity, but no elevation of blood or urinary AP in the diabetics. Urinary α-glu activity in the diabetics shows striking inhibition by glucose, and this may reflect a similar phenomenon in vivo.
Although glycohydrolase activities are elevated in patients with no detectable microangiopathy, more striking changes may be observed in patients with severe small-vessel disease. These alterations may be associated with increased glycoprotein catabolism in the diabetic, an area in need of further studies in the human and experimental diabetic animal.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
20 articles.
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