Islet Allografts Are Destroyed by Disease Occurrence in the Spontaneously Diabetic BB Rat-Reference-Cited by-同舟云学术

Islet Allografts Are Destroyed by Disease Occurrence in the Spontaneously Diabetic BB Rat

Published:1986-01-01 Issue:1 Volume:35 Page:110-114
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Prowse Stephen J¹,Bellgrau Donald¹,Lafferty Kevin J¹

Affiliation:

1. Barbara Davis Center for Childhood Diabetes, Departments of Microbiology/Immunology and Pediatrics, University of Colorado Health Sciences Center 4200 East Ninth Avenue, Box B140, Denver, Colorado 80262

Abstract

Transplantation of cultured islet and pituitary tissue from PVG (RT1C) donors to major histocompatibility complex-incompatible BB/D recipients (RT1U) results in tissue-specific destruction of the grafted islets but not of the pituitary. We interpret this response as disease occurrence in the MHC-incompatible islet graft. Islet damage is associated with eosinophil and mast cell accumulation in and around the grafted tissue. Antibody deposition is also present in tissues of the BB rat. This is suggestive of an antibody-mediated allergic reaction.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/35/1/110/354523/35-1-110.pdf

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