Absent or Delayed Preovulatory Luteinizing Hormone Surge in Experimental Diabetes Mellitus-Reference-Cited by-同舟云学术

Absent or Delayed Preovulatory Luteinizing Hormone Surge in Experimental Diabetes Mellitus

Published:1984-04-01 Issue:4 Volume:33 Page:324-327
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Katayama S¹,Brownscheidle C M¹,Wootten V¹,Lee J B¹,Shimaoka K¹

Affiliation:

1. Department of Medicine, State University of New York at Buffalo; the Endocrine Biochemistry Department, Medical Foundation of Buffalo; and the Department of Clinical Pharmacology and Therapeutics, Roswell Park Memorial Institute Buffalo, New York

Abstract

The proestrus preovulatory luteinizing hormone (LH) surge was absent or delayed in more than 56% of untreated streptozotocin-diabetic rats. Absence of LH surge was associated with anovulation. Insulin treatment for 10–14 days restored the diminished surge and ovulation frequency. Pituitary LH release in response to exogenous gonadotropin-releasing hormone administration in diabetic rats was not different from controls. Impaired hypothalamic function may comprise the basis for the increased incidence of infertility in diabetes mellitus.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/33/4/324/353136/33-4-324.pdf

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