Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes-Reference-Cited by-同舟云学术

Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes

Published:2016-06-13 Issue:7 Volume:65 Page:1757-1766
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Sellmeyer Deborah E.¹,Civitelli Roberto²,Hofbauer Lorenz C.³,Khosla Sundeep⁴,Lecka-Czernik Beata⁵,Schwartz Ann V.⁶

Affiliation:

1. Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD

2. Division of Bone and Mineral Diseases, Washington University in St. Louis School of Medicine, St. Louis, MO

3. Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Germany and Center for Regenerative Therapies Dresden, Dresden, Germany

4. Division of Endocrinology, Diabetes, Metabolism, and Nutrition Research and the Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN

5. Departments of Orthopaedic Surgery and Physiology and Pharmacology and Center for Diabetes and Endocrine Research, The University of Toledo College of Medicine and Life Sciences, Toledo, OH

6. Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA

Abstract

Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors that increase fracture risk include lower bone mass in type 1 diabetes and compromised skeletal quality and strength despite preserved bone density in type 2 diabetes, as well as the effects of comorbidities such as diabetic macro- and microvascular complications. In this Perspective, we assess the developing scientific knowledge regarding the epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging data on the prediction, treatment, and outcomes of fractures in individuals with type 1 and type 2 diabetes.

Funder

Deutsche Forschungsgemeinschaft Sonderforschungsbereiche/Transregio 67

National Institutes of Health

American Diabetes Association

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/65/7/1757/603187/db160063.pdf

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