Mitochondrial Dynamics, Diabetes, and Cardiovascular Disease
Author:
García-Peña Luis Miguel1,
Abel E. Dale1ORCID,
Pereira Renata O.1ORCID
Affiliation:
1. Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA
Abstract
Mitochondria undergo repeated cycles of fusion and fission that regulate their size and shape by a process known as mitochondrial dynamics. Numerous studies have revealed the importance of this process in maintaining mitochondrial health and cellular homeostasis, particularly in highly metabolically active tissues such as skeletal muscle and the heart. Here, we review the literature on the relationship between mitochondrial dynamics and the pathophysiology of type 2 diabetes and cardiovascular disease (CVD). Importantly, we emphasize divergent outcomes resulting from downregulating distinct mitochondrial dynamics proteins in various tissues. This review underscores compensatory mechanisms and adaptive pathways that offset potentially detrimental effects, resulting instead in improved metabolic health. Finally, we offer a perspective on potential therapeutic implications of modulating mitochondrial dynamics proteins for treatment of diabetes and CVD.
Article Highlights
Funder
NIH
Teresa Benoit Diabetes research fund to E.D.A
American Heart Association
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference78 articles.
1. Mitochondrial dynamics and metabolic regulation in cardiac and skeletal muscle;Abel;Trans Am Clin Climatol Assoc,2018
2. Mitochondrial dynamics in mammalian health and disease;Liesa;Physiol Rev,2009
3. Mitochondrial dynamics and metabolic regulation;Wai;Trends Endocrinol Metab,2016
4. Evolving concepts of mitochondrial dynamics;Dorn;Annu Rev Physiol,2019
5. The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance;Pagel-Langenickel;Endocr Rev,2010