Diazoxide-induced Diabetes Mellitus in a Hypopituitary Dwarf

Abstract

The successful application of the well-documented hyperglycemic effect of diazoxide to the management of hypoglycemic states has been previously reported. The present report describes the response of a hypopituitary dwarf to diazoxide administration. Diabetes mellitus, complicated by ketosis, was rapidly induced. Discontinuation of diazoxide therapy was followed by clearing of diabetes over the next five days. A comparison of the diazoxide response of this child to that of a child with leucine sensitivity is made. The possible mechanisms by which diazoxide induces hyperglycemia are discussed.