Studies on the Perfused Rat Liver: II. Effect of Glucagon on Gluconeogenesis-Reference-Cited by-同舟云学术

Studies on the Perfused Rat Liver: II. Effect of Glucagon on Gluconeogenesis

Published:1966-03-01 Issue:3 Volume:15 Page:188-193
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Garcia Antonio¹,Williamson Joseph R¹,Cahill George F¹

Affiliation:

1. Elliott P. Joslin Research Laboratory in the Department of Medicine, Harvard Medical School, the Diabetes Foundation, Inc. Boston, and the Department of Medicine, Peter Bent Brigham Hospital Boston, Massachusetts

Abstract

In vitro studies using the isolated perfused liver from fasted rats have demonstrated increased glucose production in the presence of glucagon. The incorporation of C-14-labeled alanine into glucose was increased, as was production of urea, suggesting a primary effect of glucagon in stimulating gluconeogenesis. Time studies showed this effect to occur in ten to fifteen minutes. Incorporation of pyruvate and lactate C-14 was also increased, as was that of HC-I4-O3.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/15/3/188/340171/15-3-188.pdf

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