Changes in Altitude Cause Unintended Insulin Delivery From Insulin Pumps-Reference-Cited by-同舟云学术

Changes in Altitude Cause Unintended Insulin Delivery From Insulin Pumps

Published:2011-08-19 Issue:9 Volume:34 Page:1932-1933
ISSN:0149-5992
Container-title:Diabetes Care
language:en
Short-container-title:

Author:

King Bruce R.¹,Goss Peter W.²,Paterson Megan A.²,Crock Patricia A.¹,Anderson Donald G.¹

Affiliation:

1. John Hunter Children’s Hospital, University of Newcastle and the Hunter Medical Research Institute, Newcastle, New South Wales, Australia

2. Gippsland Paediatrics Diabetes Unit, Sale, Victoria, Australia

Abstract

OBJECTIVE Children and adults with type 1 diabetes who receive insulin pump therapy have reported hypoglycemia during air travel. We studied the effects of atmospheric pressure on insulin pump delivery. RESEARCH DESIGN AND METHODS Ten insulin pumps were connected to capillary tubes. The effects of changes in ambient pressure on insulin delivery, bubble formation, bubble size, and cartridge plunger movement were analyzed. RESULTS During a flight (200 mmHg pressure decrease), excess insulin delivery of 0.623% of the cartridge volume occurred (P < 0.001, Student t test). In hypobaric chamber studies, bubbles developed in the insulin when the pressure decreased and displaced the insulin out of the cartridge. Pre-existing bubbles changed in size consistent with Boyle law. Cartridge plunger movement did not occur in normal flight conditions but did occur when catastrophic plane depressurization was mimicked. CONCLUSIONS Atmospheric pressure reduction causes predictable, unintended insulin delivery in pumps by bubble formation and expansion of existing bubbles.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://diabetesjournals.org/care/article-pdf/34/9/1932/608750/1932.pdf

Reference6 articles.

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3. Henry’s law [Internet]. Available from http://en.wikipedia.org/wiki/Henry%27s_law. Accessed 2 December 2010

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5. U.S. Food and Drug Administration. Guidance for industry and FDA staff—total product life cycle. Infusion pump—premarket notification [510(k)] submissions [Internet], 2010. Silver Spring, MD, U.S. Food and Drug Administration. Available from http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/ucm206153.htm. Accessed 23 March 2011

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