2021年度中国口腔医学领域高价值论文TOP100
以往我们对一篇论文的价值评估，是通过期刊影响因子或被引频次来判断，这种采用单一指标评判论文的学术价值因有失偏颇而广受诟病。北京同舟云网络信息技术有限公司创立了一种优选算法，综合考虑Metrics 期刊评分、论文被引频次、文献类型以及论文发表时间等多种因素，对每篇论文进行深度解析与计算，并赋予分值，以量化每篇论文的学术价值和影响力。本推荐表是在系统全面准确地统计中国机构作者发表的口腔医学领域国际论文的基础上（说明：口腔医学领域专家为主要完成人发表的全部论文均入选，不再筛选论文的内容主题），对每篇论文依上述方法进行计算并赋分排名而得出的，供相关学者学习、评判、参考和借鉴。
序号 | 年份 | 标题 | 期刊 | 主要完成人 | 论文评分 | 1 | 2021 | High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology | CHEM REV | 周祺惠,青岛大学,附属医院,口腔科; | 41401.77 | 2 | 2021 | Functional Hydrogels as Wound Dressing to Enhance Wound Healing | ACS NANO | 郭保林,西安交通大学,前沿科学技术研究院; | 37712.13 | 3 | 2021 | Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing | ACS NANO | 郭保林,西安交通大学,前沿科学技术研究院; | 33392.13 | 4 | 2021 | Biological and synthetic template-directed syntheses of mineralized hybrid and inorganic materials | PROG MATER SCI | 牛丽娜,空军军医大学,口腔医院,修复科; | 23189.23 | 5 | 2021 | Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer | SIGNAL TRANSDUCT TAR | 周红梅,四川大学,华西口腔医院,口腔黏膜病科; | 22466.58 | 6 | 2021 | TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment | NUCLEIC ACIDS RES | 李太文,四川大学,华西口腔医院,口腔科; | 21872.36 | 7 | 2021 | Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment | ADV FUNCT MATER | 李昂,西安交通大学,口腔医院; | 20041.62 | 8 | 2021 | Wnt/beta-catenin signaling in cancers and targeted therapies | SIGNAL TRANSDUCT TAR | 叶玲,四川大学,华西口腔医院; | 18386.58 | 9 | 2021 | The biological applications of DNA nanomaterials: current challenges and future directions | SIGNAL TRANSDUCT TAR | 林云锋,四川大学,华西口腔医院,颌面外科; | 18386.58 | 10 | 2021 | Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy | SIGNAL TRANSDUCT TAR | 卢小玲,广西医科大学,附属口腔医院; | 17426.58 | 11 | 2021 | Target Reprogramming Lysosomes of CD8+T Cells by a Mineralized Metal-Organic Framework for Cancer Immunotherapy | ADV MATER | 张玉峰,武汉大学,口腔医院,口腔种植科; | 16434.94 | 12 | 2021 | Engineered Protein Photo-Thermal Hydrogels for Outstanding In Situ Tongue Cancer Therapy | ADV MATER | 卫彦,北京大学,口腔医院,老年牙科; | 16194.94 | 13 | 2021 | Multifunctional Photoactive Hydrogels for Wound Healing Acceleration | ACS NANO | 郭保林,西安交通大学,前沿科学技术研究院; | 15152.13 | 14 | 2021 | Promoting Oral Mucosal Wound Healing with a Hydrogel Adhesive Based on a Phototriggered S-Nitrosylation Coupling Reaction | ADV MATER | 蒋欣泉,上海交通大学医学院,第九人民医院,口腔修复科; | 14394.94 | 15 | 2021 | Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model | MILITARY MED RES | 郭斌,中国人民解放军总医院,口腔科; | 13934.01 | 16 | 2021 | An Amorphous Peri-Implant Ligament with Combined Osteointegration and Energy-Dissipation | ADV MATER | 邓旭亮,北京大学,口腔医院,老年口腔科; | 12954.94 | 17 | 2021 | Biofilm-Sensitive Photodynamic Nanoparticles for Enhanced Penetration and Antibacterial Efficiency | ADV FUNCT MATER | 王宇光,北京大学口腔医院; | 12841.62 | 18 | 2021 | Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair | CELL METAB | 陈谦明,四川大学,华西医院,口腔科; | 12833.79 | 19 | 2021 | Calcium Phosphate-Reinforced Metal-Organic Frameworks Regulate Adenosine-Mediated Immunosuppression | ADV MATER | 孙志军,武汉大学,口腔医院,口腔颌面外科; | 12714.94 | 20 | 2021 | Turning cold tumors into hot tumors by improving T-cell infiltration | THERANOSTICS | 孙志军,武汉大学,口腔医院,口腔颌面外科; | 12631.07 | 21 | 2021 | A Framework Nucleic Acid Based Robotic Nanobee for Active Targeting Therapy | ADV FUNCT MATER | 林云锋,四川大学,华西口腔医院,颌面外科; | 12361.62 | 22 | 2021 | Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration | INT J ORAL SCI | 廖金凤,四川大学,华西口腔医院; | 12323.90 | 23 | 2021 | Bioinspired Conductive Silk Microfiber Integrated Bioelectronic for Diagnosis and Wound Healing in Diabetes | ADV FUNCT MATER | 王军,四川大学,华西口腔医院,正畸科; | 12001.62 | 24 | 2021 | Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing | NANO-MICRO LETT | 郭保林,西安交通大学,前沿科学技术研究院; | 11988.52 | 25 | 2021 | 3D Printing Hydrogel Scaffolds with Nanohydroxyapatite Gradient to Effectively Repair Osteochondral Defects in Rats | ADV FUNCT MATER | 范增杰,兰州大学,口腔医学院; | 11641.62 | 26 | 2021 | Biomimetic Glycopolypeptide Hydrogels with Tunable Adhesion and Microporous Structure for Fast Hemostasis and Highly Efficient Wound Healing | ADV FUNCT MATER | 陆家瑜,上海交通大学医学院,第六人民医院,口腔科; | 11401.62 | 27 | 2021 | Novel supramolecular self-healing silk fibroin-based hydrogel via host-guest interaction as wound dressing to enhance wound healing | CHEM ENG J | 郭保林,西安交通大学,前沿科学技术研究院; | 11380.36 | 28 | 2021 | Haemostatic materials for wound healing applications | NAT REV CHEM | 郭保林,西安交通大学,前沿科学技术研究院; | 10872.10 | 29 | 2021 | Haemostatic materials for wound healing applications | NAT REV CHEM | 郭保林,西安交通大学,前沿科学技术研究院; | 10872.10 | 30 | 2021 | Tetrahedral Framework Nucleic Acid-Based Delivery of Resveratrol Alleviates Insulin Resistance: From Innate to Adaptive Immunity | NANO-MICRO LETT | 林云锋,四川大学,华西口腔医院,颌面外科; | 10788.52 | 31 | 2021 | Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway | INT J ORAL SCI | 周红梅,四川大学,华西口腔医院,口腔黏膜病科; | 10763.90 | 32 | 2021 | Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade | INT J ORAL SCI | 李宇,四川大学,华西口腔医院,正畸科; | 10643.90 | 33 | 2021 | DNA-catalyzed efficient production of single-stranded DNA nanostructures | CHEM-US | 顾宏周,复旦大学上海医学院,基础医学院; | 10243.44 | 34 | 2021 | Defect Engineering in Lead Zirconate Titanate Ferroelectric Ceramic for Enhanced Electromechanical Transducer Efficiency | ADV FUNCT MATER | 韩冰,北京大学,口腔医院; | 10201.62 | 35 | 2021 | Molecular mechanisms of inhibiting glucosyltransferases for biofilm formation in Streptococcus mutans | INT J ORAL SCI | 邹静,四川大学,华西口腔医院,儿童口腔科; | 10163.90 | 36 | 2021 | Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis | NANO-MICRO LETT | 张玉峰,武汉大学,口腔医院,口腔种植科; | 10068.52 | 37 | 2021 | Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging | INT J ORAL SCI | 王琪,四川大学,华西口腔医院,修复科; | 9923.90 | 38 | 2021 | Oxygen Self-Sufficient Nanoplatform for Enhanced and Selective Antibacterial Photodynamic Therapy against Anaerobe-Induced Periodontal Disease | ADV FUNCT MATER | 王林,吉林大学,口腔医院,种植修复科; | 9841.62 | 39 | 2021 | Therapeutic siCCR2 Loaded by Tetrahedral Framework DNA Nanorobotics in Therapy for Intracranial Hemorrhage | ADV FUNCT MATER | 林云锋,四川大学,华西口腔医院,颌面外科; | 9841.62 | 40 | 2021 | Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium | INT J ORAL SCI | 林正梅,中山大学,附属口腔医院,牙体牙髓病科; | 9803.90 | 41 | 2021 | Novel MSX1 variants identified in families with nonsyndromic oligodontia | INT J ORAL SCI | 韩冬,北京大学,口腔医学院; | 9683.90 | 42 | 2021 | DNAs catalyzing DNA nanoconstruction | CHEM-US | 顾宏周,复旦大学上海医学院,基础医学院; | 9643.44 | 43 | 2021 | Review of a new bone tumor therapy strategy based on bifunctional biomaterials | BONE RES | 钱志勇,四川大学,华西医院,生物治疗国家重点实验室; | 9642.93 | 44 | 2021 | Palladium Nanocrystals-Engineered Metal-Organic Frameworks for Enhanced Tumor Inhibition by Synergistic Hydrogen/Photodynamic Therapy | ADV FUNCT MATER | 林开利,上海交通大学医学院,第九人民医院,口腔颅颌面科; | 9601.62 | 45 | 2021 | The Neuroprotective Effect of MicroRNA-22-3p Modified Tetrahedral Framework Nucleic Acids on Damaged Retinal Neurons Via TrkB/BDNF Signaling Pathway | ADV FUNCT MATER | 林云锋,四川大学,华西口腔医院,颌面外科; | 9601.62 | 46 | 2021 | Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells | INT J ORAL SCI | 张冬梅,中国医科大学,口腔医学院,牙周科 ; | 9563.90 | 47 | 2021 | PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling | INT J ORAL SCI | 张平,四川大学,华西口腔医院; | 9563.90 | 48 | 2021 | FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma | INT J ORAL SCI | 陈谦明,四川大学,华西医院,口腔科; | 9563.90 | 49 | 2021 | Analyses of oligodontia phenotypes and genetic etiologies | INT J ORAL SCI | 吴轶群,上海交通大学医学院,第九人民医院,口腔第二门诊部; | 9563.90 | 50 | 2021 | Cigarette smoke promotes oral leukoplakia via regulating glutamine metabolism and M2 polarization of macrophage | INT J ORAL SCI | 王文梅,南京市口腔医院,,口腔内科; | 9563.90 | 51 | 2021 | Bio-Multifunctional Hydrogel Patches for Repairing Full-Thickness Abdominal Wall Defect | ADV FUNCT MATER | 周祺惠,青岛大学,附属医院,口腔科; | 9361.62 | 52 | 2021 | Injectable In Situ Induced Robust Hydrogel for Photothermal Therapy and Bone Fracture Repair | ADV FUNCT MATER | 卫彦,北京大学,口腔医院,老年牙科; | 9361.62 | 53 | 2021 | Near-Infrared II Light-Triggered Robust Carbon Radical Generation for Combined Photothermal and Thermodynamic Therapy of Hypoxic Tumors | ADV FUNCT MATER | 刘习强,中山大学,附属口腔医院,口腔颌面外科; | 9361.62 | 54 | 2021 | Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor-activated Smad pathway | BIOMATERIALS | 林开利,上海交通大学医学院,第九人民医院,口腔颅颌面科; | 9359.54 | 55 | 2021 | Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs | SCI ADV | 杨驰,上海交通大学医学院,第九人民医院,口腔外科; | 9342.22 | 56 | 2021 | External cervical resorption-a review of pathogenesis and potential predisposing factors | INT J ORAL SCI | 邓旭亮,北京大学,口腔医院,老年口腔科; | 9323.90 | 57 | 2021 | Covalent grafting of hyperbranched poly-L-lysine on Ti-based implants achieves dual functions of antibacteria and promoted osteointegration in vivo | BIOMATERIALS | 杨国利,浙江大学医学院,附属口腔医院,口腔种植科; | 9239.54 | 58 | 2021 | Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma | INT J ORAL SCI | 王成,中山大学,附属口腔医院,口腔颌面外科; | 9203.90 | 59 | 2021 | Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage | INT J ORAL SCI | 李继遥,四川大学,华西口腔医院,口腔科; | 9203.90 | 60 | 2021 | USP34 regulates tooth root morphogenesis by stabilizing NFIC | INT J ORAL SCI | 袁泉,四川大学,华西口腔医院,口腔种植科; | 9203.90 | 61 | 2021 | PER2-mediated ameloblast differentiation via PPAR gamma/AKT1/beta-catenin axis | INT J ORAL SCI | 宋亚玲,武汉大学,口腔医院,牙体牙髓科; | 9203.90 | 62 | 2021 | The vicK gene of Streptococcus mutans mediates its cariogenicity via exopolysaccharides metabolism | INT J ORAL SCI | 胡涛,四川大学,华西口腔医院,预防口腔科; | 9203.90 | 63 | 2021 | SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation | INT J ORAL SCI | 江潞,四川大学,华西口腔医院,粘膜病科; | 9203.90 | 64 | 2021 | Two-Photon Absorption Induced Cancer Immunotherapy Using Covalent Organic Frameworks | ADV FUNCT MATER | 孙志军,武汉大学,口腔医院,口腔颌面外科; | 9121.62 | 65 | 2021 | Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets | MOL CELL | 陈谦明,四川大学,华西医院,口腔科; | 9104.39 | 66 | 2021 | Individualized plasticity autograft mimic with efficient bioactivity inducing osteogenesis | INT J ORAL SCI | 夏海斌,武汉大学,口腔医学院,修复科; | 9083.90 | 67 | 2021 | Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws | INT J ORAL SCI | 李铁军,北京大学,口腔医院,病理科; | 9083.90 | 68 | 2021 | Transforming growth factor-beta 1-induced N-cadherin drives cell-cell communication through connexin43 in osteoblast lineage | INT J ORAL SCI | 谢静,四川大学,华西口腔医院; | 9083.90 | 69 | 2021 | Tetrahedral framework nucleic acids act as antioxidants in acute kidney injury treatment | CHEM ENG J | 林云锋,四川大学,华西口腔医院,颌面外科; | 8980.36 | 70 | 2021 | Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection | NAT COMMUN | 李彦,中山大学,附属口腔医院,口腔修复科; | 8967.25 | 71 | 2021 | A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery | NAT COMMUN | 王剑,四川大学,华西口腔医院,口腔修复科; | 8967.25 | 72 | 2021 | miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition | INT J ORAL SCI | 范志朋,首都医科大学,附属北京口腔医院; | 8963.90 | 73 | 2021 | Removal of nonimpacted third molars alters the periodontal condition of their neighbors clinically, immunologically, and microbiologically | INT J ORAL SCI | 陈发明,空军军医大学,口腔医院,牙周病科; | 8963.90 | 74 | 2021 | Construction of hollow polydopamine nanoparticle based drug sustainable release system and its application in bone regeneration | INT J ORAL SCI | 孙宏晨,吉林大学,口腔医院,病理科; | 8963.90 | 75 | 2021 | Single-cell characterization of monolayer cultured human dental pulp stem cells with enhanced differentiation capacity | INT J ORAL SCI | 刘欢,武汉大学,口腔医院; | 8963.90 | 76 | 2021 | Treating LRRK2-Related Parkinson's Disease by Inhibiting the mTOR Signaling Pathway to Restore Autophagy | ADV FUNCT MATER | 林云锋,四川大学,华西口腔医院,颌面外科; | 8881.62 | 77 | 2021 | SPDEF suppresses head and neck squamous cell carcinoma progression by transcriptionally activating NR4A1 | INT J ORAL SCI | 夏娟,中山大学,附属口腔医院,口腔粘膜病诊室; | 8843.90 | 78 | 2021 | Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3 | INT J ORAL SCI | 赖文莉,四川大学,华西口腔医院,口腔正畸科; | 8843.90 | 79 | 2021 | Hard tissue stability after guided bone regeneration: a comparison between digital titanium mesh and resorbable membrane | INT J ORAL SCI | 蔡潇潇,四川大学,华西口腔医院,种植科; | 8843.90 | 80 | 2021 | Role of connexin 43 in odontoblastic differentiation and structural maintenance in pulp damage repair | INT J ORAL SCI | 胡涛,四川大学,华西口腔医院,预防口腔科; | 8843.90 | 81 | 2021 | Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase | INT J ORAL SCI | 潘亚萍,中国医科大学,附属口腔医院,牙周病科; | 8843.90 | 82 | 2021 | Magnesium Oxide-Assisted Dual-Cross-Linking Bio-Multifunctional Hydrogels for Wound Repair during Full-Thickness Skin Injuries | ADV FUNCT MATER | 李道伟,吉林大学,口腔医院,口腔生物学教研室; | 8761.62 | 83 | 2021 | A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization | BIOMATERIALS | 王林,吉林大学,口腔医院,种植修复科; | 8759.54 | 84 | 2021 | TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration | NAT COMMUN | 陈卓凡,中山大学,附属口腔医院,口腔种植科; | 8727.25 | 85 | 2021 | Development of a biomechanical model for dynamic occlusal stress analysis | INT J ORAL SCI | 王美青,空军军医大学,口腔医院,颞下颌关节病科; | 8723.90 | 86 | 2021 | Three-dimensional reconstruction of systematic histological sections: application to observations on palatal shelf elevation | INT J ORAL SCI | 石冰,四川大学,华西口腔医院,口腔颌面外科; | 8723.90 | 87 | 2021 | The effects of altered BMP4 signaling in first branchial-arch-derived murine embryonic orofacial tissues | INT J ORAL SCI | 邵美瑛,四川大学,华西第四医院,口腔科; | 8723.90 | 88 | 2021 | Copper ferrite heterojunction coatings empower polyetheretherketone implant with multi-modal bactericidal functions and boosted osteogenicity through synergistic photo/Fenton-therapy | CHEM ENG J | 谢璐,四川大学,华西口腔医学院; | 8620.36 | 89 | 2021 | Stimuli-responsive conductive hydrogels: design, properties, and applications | MATER CHEM FRONT | 郭保林,西安交通大学,前沿科学技术研究院; | 8472.10 | 90 | 2021 | Safeguarding Osteointegration in Diabetic Patients: A Potent "Chain Armor" Coating for Scavenging ROS and Macrophage Reprogramming in a Microenvironment-Responsive Manner | ADV FUNCT MATER | 陈陶,重庆医科大学,附属口腔医院,修复科; | 8401.62 | 91 | 2021 | Advancing application of mesenchymal stem cell-based bone tissue regeneration | BIOACT MATER | 金岩,空军军医大学,口腔医院,口腔组织病理科; | 8352.10 | 92 | 2021 | Bioswitchable Delivery of microRNA by Framework Nucleic Acids: Application to Bone Regeneration | SMALL | 蔡潇潇,四川大学,华西口腔医院,种植科; | 8339.66 | 93 | 2021 | A biodegradable antibacterial alginate/carboxymethyl chitosan/Kangfuxin sponges for promoting blood coagulation and full-thickness wound healing | INT J BIOL MACROMOL | 周祺惠,青岛大学,附属医院,口腔科; | 8288.00 | 94 | 2021 | Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration | CELL DEATH DIFFER | 胡成虎,空军军医大学,口腔医院; | 8248.88 | 95 | 2021 | Genetically Programmable Fusion Cellular Vesicles for Cancer Immunotherapy | ANGEW CHEM INT EDIT | 于光涛,南方医科大学; | 8172.72 | 96 | 2021 | High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing | J ADV CERAM | 焦婷,上海交通大学医学院,第九人民医院,口腔修复科; | 8167.19 | 97 | 2021 | 4D Printing of Multi-Responsive Membrane for Accelerated In Vivo Bone Healing Via Remote Regulation of Stem Cell Fate | ADV FUNCT MATER | 王慧明,浙江大学,附属口腔医院,口腔颌面外科; | 8161.62 | 98 | 2021 | Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties | CELL MOL IMMUNOL | 林正梅,中山大学,附属口腔医院,牙体牙髓病科; | 8160.45 | 99 | 2021 | Dual stimuli-responsive metal-organic framework-based nanosystem for synergistic photothermal/pharmacological antibacterial therapy | ACTA BIOMATER | 孙明,安徽医科大学,第一附属医院,口腔科; | 8085.79 | 100 | 2021 | Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis | CELL PROLIFERAT | 周永胜,北京大学,口腔医院,口腔修复科; 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