教育、工作背景 1982年获中科院遗传所硕士,1990年获美国依阿华大学博士,1990~1993年在哥伦比亚大学Eric R. Kandel(2000年Nobel 医学和生理学奖获得者)实验室进行博士后研究。 曾任美国 Genomics Institute of the Novartis Research Foundation 研究员、Memory Pharmaceutical公司和美国Bayer 公司任科学家。2002年9月全职回国,任教育部 “脑功能基因组学重点实验室”主任,上海市“脑功能基因组学重点实验室”执行主任,华东师范大学“脑功能基因组学研究所”执行所长,华东师范大学“紫江特聘教授”,华东师范大学终身教授,教育部科技委员会委员,国家科技部“973计划”首席科学家,并先后主持两项科技部“863计划”项目。 发表文章: Hu, Y., H. Liang, and Y. Q. Jiang. (1989). Study on the mechanism of micronucleoli formation by laser microirradiation. Cell Biophysics 14: 257‑269 Hu, Y. and T. W. Conway. (1993) 2‑Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo. J. Interferon Res. 13: 323-328 Hu, Y., A. Barzilai, M. Chen, C. Bailey and E. R. Kandel (1993). 5-HT and cAMP induce the formation of coated pits and vesicles and increase the expression of clathrin light chain in sensory neurons of Aplysia. Neuron 10: 921-929 Zhuo, M., Y. Hu, C. Schultz, E. R. Kandel and R. D. Hawkins (1994). Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature 368: 635-639 Yamasaki, S., Y. Hu, T. Binz, A. Kalkuhl, H. Kurazono, T. Tamura, R. Jahn, E. R. Kandel and H. Niemann (1994). Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: Structure and proteolysis by tetanus toxin, and botulinal neurotoxins type D and F. Proc. Natl. Acad. Sci. U.S.A. 91: 4688-4692 Martin, K. C, Y. Hu, B. Armitage, S. A. Siegelbaum, E. R. Kandel and B-K Kaang. (1995). Evidence for synaptotagmin as an inhibitory clamp on synaptic vesicle release in Aplysia neurons. Proc. Natl. Acad. Sci. U. S. A. 92: 11307-11311 (First three authors made equal contributions) Skehel. P. A., B. A. Armitage, D. Bartsch, Y. Hu, B-K Kaang, S.A. Siegelbaum, E. R. Kandel and K. C. Martin. (1995). Proteins functioning in synaptic transmission at the sensory to motor synapse of Aplysia. J. Neuropharmacology 34: 1379-1385 Hu, Y., B. T. Bloompuist, L. J. Cornfield, L. B. DeCarr, J. R. Flores-Riveros, L. Friedman, P. Jiang, L. Lewis-Higgins, Y. Sadlowski, J. Schaefer, N. Velazquez and M. L. McCaleb. (1996). Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J. Biol. Chem. 271: 26315-26319 Li, K., J. Zhang and Y. Hu. (1999). Targeting PKC-alpha for cancer gene therapy: effect of ISIS-3521. Current Opinion in Molecular Therapeutics 1: 393-398 Rampon, C., C. H. Jiang, H. Dong, D. J. Lockhart, P. G. Schultz, J. Z. Tsien and Y. Hu*.(2000). Effects of environmental enrichment on gene expression in the brain. Proc. Natl. Acad. Sci. U. S. A. 97: 12880-12884 Jiang, C. J., J. Z. Tsien, P.G. Schultz and Y. Hu*. (2001). The Effects of Aging on Gene Expression in the Hypothalamus and Cortex of Mice. Proc. Natl. Acad. Sci. U. S. A. 98: 1930-1934 Hu, Y. and Tsien J. Z. (2002).Functional Genomics: Profiling the Brain and Cognition with DNA Microarrays. Applied Genomics and Proteomics. 1 (4): 219-226 Wang D, Deng C, Bugaj-Gaweda B, Kwan M, Gunwaldsen C, Leonard C, Xin X, Hu Y, Unterbeck A, De Vivo. (2003) Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7. Cell Signal. 15 (9): 883-891 Hu Y. and Joe Z. Tsien (2003) Exploring the Brain Secret. Scientific American (Chinese Edition)10:50-54 Jiang C, Chen G, Zeng X, Ouyang K, Y. Hu*(2003) Generation of a bioactive neuropeptide in a cell-free system. Anal Biochem. 316(1):34-40 GAO Hong, OU-YANG Ke-Qing, ZHENG Xu-Xu, XU Zhi-Liang, Yinghe HU, CAI Shao-Xi. (2003) High throughput screening method of identifying agonist for muscarinic receptor. Chinese Pharmacological Bulletin. 19(7):776-779 XU Zhi-Liang, GAO Hong, OU-YANG Ke-Qing, ZHENG Xu-Xu, CAI Shao-Xi, Yinghe HU. (2003) Functional assay and high throughput screening for G-protein coupled receptors. Chinese Pharmacological Bulletin. 19(12):1330-1336 Zhang J, Meng B, Liao D, Zhou L, Zhang X, Chen L, Guo Z, Peng C, Zhu B, Lee PP, Xu X, Zhou T, Deng Z, Hu Y, Li K. (2003) De novo synthesis of PCR templates for the development of SARS diagnostic assay. Mol Biotechnol. 25(2):107-112 Zhi-liang XU, Hong GAO, Ke-qing OU-YANG, Shao-xi Cai, Y. Hu*. (2004) Establishment of a cell-based assay to screen regulators for Klotho gene promoter. Acta Pharmacologica Sini 25(9): 1165-1170 Xianchun Li, Y. Hu*. (2005) Gene expression profiling reveals the mechanism of action of anticonvulsant durg QYS. Brain Research Bulletin 66: 99-105 Xuxu Zheng, Yinghe Hu, Jianhui Liu and Keqing Ouyang. (2005) Screening of active compounds as neuromedin U2 receptor agonist from natural products. Bioorganic & Medicinal Chemistry Letters 15: 4531-4535 Bing Mei, Chunxia Li , Suzhen Dong, Cecilia H. Jiang, Huimin Wang, Y. Hu*. (2005) Distinct gene expression profiles in hippocampus and amygdala after fear conditioning. Brain Research Bulletin 67:1-12 Nan JIANG, Ke-qing OU-YANG, Shao-xi CAI, Yinghe HU, Zhi-liang XU. (2005) Identification of human dopamine D1-like receptor agonist using a cellbased functional assay. Acta Pharmacologica Sinica 26(10): 1181-1186 Xianchun Li, Hui Kuang, Nan Jiang, Y. Hu*. (2005) Involvement of Scn1b and Kcna1 ion channels in audiogenic seizures and PTZ-induced epilepsy. Epilepsy Research. 66:155-163 Zhen-Xia Qin, Feng Gu, Y. Hu*. (2005) Caspase-independent Prpgrammed Cell Death.Chinese Journal of Cell Biology. 27(3):277-280. Xianchun Li, Qingxiong Yang , Y. Hu*. (2006) Regulation of the expression of GABAA receptor subunits by an antiepileptic drug QYS. Neuroscience Letters. 392:145-149 Huimin Wang, Y. Hu, Joe Z. Tsien.(2006) Molecular and Cellular Mechanisms of Memory Consolidation and Storage. Progress in Neurobiology. 2006 Jun;79(3):123-35. Liwen Sun, Y. Hu*.(2006) Protective effects of EUK4010 on beta-Amyloid(1-42) induced degeneration of neuronal cells. European Journal of Neuroscience. 2006 Aug;24(4):1011-9. Fang Liyan, Y. Hu* (2006) Chemical Genetic Analysis Reveals the Effects of NMU2R on the Expression of Peptide Hormones. Neuroscience Letters. 2006 Aug 14;404(1-2):148-53. Bo Meng, Yue-woon Lui, Shi Meng, Changxiu Cao, Y. Hu*.(2006) Identification of Effective siRNA Blocking the Expression of SARS Viral Envelope E and RDRP Genes. Molecular Biotechnology. 2006 Jun;33(2):141-8. Li C, Niu W, Jiang CH, Y. Hu*. (2007) Effects of enriched environment on gene expression and signal pathways in cortex of hippocampal CA1 specific NMDAR1 knockout mice. Brain Res Bull. 71(6):568-77. Niu W, Jiang N, Y. Hu*. (2007) Detection of proteins based on amino acid sequences by multiple aptamers against tripeptides. Anal Biochem. 362(1):126-35. Wang L, Bai J, Y. Hu*. (2007) Identification of the RA response element and transcriptional silencer in human alphaCaMKII promoter. Mol Biol Rep.2008,35 (1), 37-44 Dong SZ., P. Wu, CX Li, Y. Hu*. (2007) Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. European Journal of Neuroscience. 26: 101-112. Liu JH., F. Yin X. Zheng, J. Jing, Y. Hu (2007) Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway. Neurochemistry International. 51: 361-369 Qian Shen, Qiang Sun, Xiaoluan Wei, Juan Dong, Rong Zhang, Pu Wu, Yujuan Jin, Jie Feng, Houda Li and Yinghe Hu* (2007) Generation and Characterization of Islet Cell Tumor in pTet-on/pTRE-SV40Tag Double-Transgenic Mice Model. J. Biosci. Bioeng., 104, 14-21 Wu Pu , Shen Qian, Dong Suzhen, Y. Hu*, Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice ,Neurobiol Aging. 2008 Oct;29(10):1502-11. Epub 2007 May 17. Qin Zhenxia, Sun Zhongwei, Huang J, Hu Yinghe, Wu Zirong, Mei Bing, Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42)., Neurosci Lett. 2008 Oct 31;444(3):217-21. Epub 2008 Aug 22. Zheng Zhao and Yinghe Hu. (2008) Genome-wide expression profiles in amygdala and hippocampus in mice after fear conditioning. Handbook of Neurochemistry and Molecular Neurobiology (3rd Edition, Vol.13) (Submitted) Zhu, M.-J., Sun, L.-J., Liu, Y.-Q., Feng, Y.-L., Tong, H.-T., Hu, Y.-H. and Zhao, Z.,* Blood F2-isoprostanes are significantly associated with the abnormalities of lipid status in rats with steatosis. World Journal of Gastroenterology 2008; 14:4677-4683 Gu, F., Zhu, M.-J., Shi, J.-T., Hu, Y.-H. and Zhao, Z.,* Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice. Neuroscience Letters 2008; 440:44-48 Gu, F., Shi J.-T., Wen, Y., Fan, H., Hu, J.-F., Hu, Y.-H. and Zhao, Z.,* Translational responses of NR2B overexpression in the cerebral cortex of transgenic mice: a liquid chromatography-based proteomic approach. Brain Research 2008, doi:10.1016 /j.brainres. 2008.10.039 Zhu, M.-J., Gu, F., Shi, J.-T., Hu, J.-F., Hu, Y.-H. and Zhao, Z.,* Increased oxidative stress and astrogliosis responses in conditional double knockout mice of Alzheimer-like presenilin-1 and presenilin-2. Free Radic Biol Med 2008, 45(10):1493-1499 Wu SB., Zhao Y., Fan H., Hu YH., Hu J F., (2008) New Guaiane Sesquiterpenes and Furanocoumarins from Notopterygium incisum. Planta Medica, 74: 1812-1817. Zhang Z., Wang D., Zhao,Y., Gao H., Hu, YH., Hu JF., (2008).Fructose-derived Carbohydrates from Alisma orientalis. Natural Product Research, in press Wu SB, Yu YH., Hu YH., Hu, JF., (2008) A New Dimeric Furanocoumarin from Notopterygium incisum Chin. Chem. Lett. 19: 940-942
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