姓名： 王建莉职务： 系主任职称： 教授学历： 博士专业: 免疫学 所属院系: 基础医学系 研究方向: 树突状细胞相关的免疫学及其来源的免疫新分子的克隆和功能的研究；肿瘤的免疫治疗和基因治疗的基础和临床研究；免疫应答及其调节的细胞及分子机制； 电话: 0571-88208283 信箱: jlwang@zju.edu.cn 个人主页: 个人简介浙江大学免疫系主任，浙江大学免疫学研究所教授、博士生导师，浙江大学免疫学科带头人。主要从事恶性肿瘤及传染病基因治疗与免疫治疗的基础和临床研究。在国内首先开展了树突状细胞与肿瘤细胞融合方法制备新型肿瘤瘤苗研究及肿瘤细胞与树突状细胞来源的Exosomes新型疫苗研究。在国内外专业期刊上发表论文六十余篇，部分研究成果已达到国际先进水平，以第一申请人申请国家发明专利12项，已授权10项。主持并开展了树突状细胞为基础的免疫治疗研究，建立了我国恶性肿瘤树突状细胞治疗的技术规范。该研究项目通过SFDA新药审评，目前已完成II临床期研究，并报SFDA申请三期批文。学历和研究经历：1981.8-1986.8 第二军医大学军医系 学士1986.9-1989.8 第二军医大学生理学教研室 硕士1989.9-1992.8 海军医学研究所流行病研究室 助研1992.9-1994.7 第二军医大学长征医院免疫室 博士1994.8-1996.10 第二军医大学免疫学教研室 讲师1996.10-1998.10 美国克里夫兰临床医学中心 博士后1998.11-1999.7 第二军医大学医学遗传教研室 讲师1999.7-1999.9 第二军医大学医学遗传教研室 副教授1999.9-2000.10 美国明尼苏达大学癌症中心 Research Associate2000.10－至今 浙江大学免疫学研究所 教授2003.9-至今 浙江大学免疫学研究所 博士生导师2006.9-至今 浙江大学医学院免疫系 主任主要论文：1. Cai Z, Zhang W, Li M, Yue Y, Yang F, Yu L, Cao X, Wang J. TGF-beta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells. Cell Mol Immunol. 2010 Jan;7(1):35-43.2. Rui Y, Liu X, Li N, Jiang Y, Chen G, Cao X, Wang J. . PECAM-1 Ligation Negatively Regulates TLR4 Signaling in Macrophages.J Immunol. 2007 Dec 1;179(11):7344-51. (通讯作者)3. Yang Y, Xiu F, Cai Z, Wang J, Wang Q, Fu Y, Cao X. Increased induction of antitumor response by exosomes derived from interleukin-2 gene-modified tumor cells. J Cancer Res Clin Oncol. 2007 Jun;133(6):389-99.4. Xiu F, Cai Z, Yang Y, Wang X, Wang J, Cao X. Surface anchorage of superantigen SEA promotes induction of specific antitumor immune response by tumor-derived exosomes. J Mol Med. 2007 May;85(5):511-21 (共同通讯作者)5. Yan X, Xiu F, An H, Wang X, Wang J, Cao X. Fever range temperature promotes TLR4 expression and signaling in dendritic cells. Life Sci. 2007 Jan 2;80(4):307-13.6. Zhang Y, Wang X, Xiang Z, Li H, Qiu J, Sun Q, Wan T, Li N, Cao X, Wang J. Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein. Int J Mol Med.2007;19(1):55-63. (通讯作者)7. Wang Q, Li N, Wang X, Shen J, Hong X, Yu H, Zhang Y, Wan T, Zhang L, Wang J, Cao X. Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells. Life Sci. 2007 Jan 9;80(5):420-9.8. Li D, Yu H, Huang H, Shen F, Wu X, Li J, Wang J, Cao X, Wang Q, Tang G. FGF receptor-mediated gene delivery using ligands coupled to polyethylenimine. J Biomater Appl. 2007 Sep;22(2):163-80.9. Wang J, Cao X, Zhang W, Ye T, Tani K. Treatment of leukemia with fibroblast-mediated interferon-alpha gene therapy alone or in combination with doxorubicin. Leukemia Res, 1996;20(5):379-38410. Wang J, Saffold S, Cao X, Krauss J, Chen W. Eliciting T cell immunity Against poorly immunogenic tumors by immunization with dendritic cell-tumor fusion vaccines. The Journal of Immunology. 1998; 161: 5516-552411. Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X. Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. Biochem Biophys Res Commun. 2001;281(4):878-883. (共同第一作者)12. He X, Wang J, Guo Z, Liu Q, Chen T, Wang X, Cao X. Requirement for ERK activation in sinomenine-induced apoptosis of macrophages. Immunol Lett. 2005, 98(1): 91-96 (共同第一作者)13. Sun W, He X, Guo Z, Wang Q, Li X, Rayner J, Zhang L, Wang J, Cao X. IL-12p40-overexpressing immature dendritic cells induce T cell hyporesponsiveness in vitro but accelerate allograft rejection in vivo: Role of NK cell activation and interferon-gamma production. Immunol Lett. 2004, 94:191-199 （共同通讯作者）.14. Chen W, Wang J, Shao C, Liu S, Yu Y, Wang Q, Cao X. Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol. 2006 ;36(6):1598-607.15. Wang Q，Liu Y，Wang J，Ding G，ZhangW，Chen G，Zhang M，Zheng S, Cao X. Induction of Allospecific Tolerance by Immature Dendritic Cells Genetically Modified to Express Soluble TNF Receptor. The Journal of Immunology. 2006;177(4):2175-85. (Q.W and Y.L. contributed equally to this study)16. Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X. Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem Biophys Res Commun. 2006 ; 345(3):1122-30.17. Tang H, Guo Z, Zhang M, Wang J, Chen G, Cao X. Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL- 10. Blood. 2006;108(4) :1189-97.18. Chen W, Wang J, An H, Zhou J, Zhang L, Cao X. Heat shock up-regulates TLR9 expression in human B cells through activation of ERK and NF-κB signal pathways. Immunol Lett. 2005, 98(1): 153-159.19. Pan J, Zhang M, Wang J, Wang Q, Xia D, Sun W, Zhang L, Yu H, Cao X. Intratumoral injection of interferon-gamma gene-modified dendritic cells elicits potent antitumor effects: effective induction of tumor-specific CD8(+) CTL response. J Cancer Res Clin Oncol. 2005 ;131(7):468-78.20. Sun H, Li N, Wang X, Chen T, Shi L, Zhang L, Wang J, Wan T, Cao X. Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells. Mol Cell Biochem. 2005; 269(1-2):85-9421. Pan J, Zhang M, Wang J, Wang Q, Xia D, Sun W, Zhang L, Yu H, Liu Y, Cao X. Interferon-gamma is an autocrine mediator for dendritic cell maturation. Immunol Lett. 2004, 94(1-2): 141-151.22. Zhang M, Tang H, Guo Z, An H, Zhu X, Song W, Guo J, Huang X, Chen T, Wang J, Cao X. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells, Nature Immunology. 2004, 5(11):1124-1133.23. Chen T, Guo J, Yang M, Han C, Zhang M, Chen W, Liu Q, Wang J, Cao X. Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression. Blood. 2004; 103(2)： 413-421.