Regulatory Role of miR-15a/16 in Gastric Cancer Treatment

Abstract

Gastric cancer has a high incidence rate worldwide; it is particularly important to determine the therapeutic efficacy of available treatments and to determine the prognosis of gastric cancer due to its insidious onset and lack of specific symptoms in the early stage (most patients are diagnosed in the middle or late stage). Recent studies have revealed that altered expression of microRNAs plays a pivotal role in immune checkpoints and various cellular processes in gastric cancer. miRNAs have gradually become biomarkers and therapeutic targets in cancer because of their specificity and high sensitivity. In this article, we review the expression of miR-15a/16 and its therapeutic efficacy in gastric cancer and discuss its impact on signaling pathways and its prognostic importance to provide better clinical treatment options for patients.