Nanorobots to Treat Candida albicans Infection

Author:

Hu Yanling1,Zeng Guisheng2,Wang Yue23,Yang Dongliang24ORCID

Affiliation:

1. College of Life and Health, Nanjing Polytechnic Institute, Nanjing 210048, China.

2. A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #05-13 Immunos, Singapore 138648, Singapore.

3. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.

4. Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing 211816, China.

Abstract

Candida albicans is an opportunistic fungal pathogen of humans. It causes a variety of infections ranging from superficial mucocutaneous conditions to severe systemic diseases that result in substantial morbidity and mortality. This pathogen frequently forms biofilms resistant to antifungal drugs and the host immune system, leading to treatment failures. Recent research has demonstrated the potential of nanorobots to penetrate biological barriers and disrupt fungal biofilms. In this perspective paper, we provide a brief overview of recent breakthroughs in nanorobots for candidiasis treatment and discuss current challenges and prospects.

Funder

National Medical Research Council of Singapore

Publisher

American Association for the Advancement of Science (AAAS)

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