Fluid Shear Stress-Induced Alignment of Cultured Vascular Smooth Muscle Cells-Reference-Cited by-同舟云学术

Fluid Shear Stress-Induced Alignment of Cultured Vascular Smooth Muscle Cells

Published:2001-10-02 Issue:1 Volume:124 Page:37-43
ISSN:0148-0731
Container-title:Journal of Biomechanical Engineering
language:en
Short-container-title:

Author:

Lee Ann A.¹,Graham Dionne A.¹,Dela Cruz Sheila¹,Ratcliffe Anthony¹,Karlon William J.²

Affiliation:

1. Advanced Tissue Sciences, Inc., La Jolla, CA 92037

2. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093

Abstract

The study objectives were to quantify the time- and magnitude-dependence of flow-induced alignment in vascular smooth muscle cells (SMC) and to identify pathways related to the orientation process. Using an intensity gradient method, we demonstrated that SMC aligned in the direction perpendicular to applied shear stress, which contrasts with parallel alignment of endothelial cells under flow. SMC alignment varied with the magnitude of and exposure time to shear stress and is a continuous process that is dependent on calcium and cycloskeleton based mechanisms. A clear understanding and control of flow-induced SMC alignment will have implications for vascular tissue engineering.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Link

http://asmedigitalcollection.asme.org/biomechanical/article-pdf/124/1/37/5562122/37_1.pdf

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