The Elephant in the Cell: Nuclear Mechanics and Mechanobiology-Reference-Cited by-同舟云学术

The Elephant in the Cell: Nuclear Mechanics and Mechanobiology

Published:2022-03-11 Issue:8 Volume:144 Page:
ISSN:0148-0731
Container-title:Journal of Biomechanical Engineering
language:en
Short-container-title:

Author:

Jones Michelle L.¹,Dahl Kris Noel²³,Lele Tanmay P.⁴⁵⁶,Conway Daniel E.⁷,Shenoy Vivek⁸⁹¹⁰,Ghosh Soham¹¹,Szczesny Spencer E.¹²¹³¹⁴

Affiliation:

1. Clinical Insights, Ltd , 60 Summer Duck Way, Pittsburgh, PA 15238

2. Department of Chemical Engineering, Carnegie Mellon University , Doherty Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213 ; , 120 Broadway 15th Floor, New York City, NY 10271

3. Forensics Department, Thornton Tomasetti , Doherty Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213 ; , 120 Broadway 15th Floor, New York City, NY 10271

4. Department of Biomedical Engineering, Texas A&M University , 101 Bizzell Street, College Station, TX 77840 ; , 101 Bizzell Street, College Station, TX 77840 ; , 101 Bizzell Street, College Station, TX 77840

5. Department of Chemical Engineering, Texas A&M University , 101 Bizzell Street, College Station, TX 77840 ; , 101 Bizzell Street, College Station, TX 77840 ; , 101 Bizzell Street, College Station, TX 77840

6. Department of Translational Medical Sciences, Texas A&M University , 101 Bizzell Street, College Station, TX 77840 ; , 101 Bizzell Street, College Station, TX 77840 ; , 101 Bizzell Street, College Station, TX 77840

7. Department of Biomedical Engineering, Virginia Commonwealth University , 601 West Main Street, P.O. Box 843068, Richmond, VA 23284

8. Materials Science and Engineering Bioengineering, University of Pennsylvania , 3231 Walnut Street, Philadelphia, PA 19104 ; , 3231 Walnut Street, Philadelphia, PA 19104 ; , 3231 Walnut Street, Philadelphia, PA 19104

9. Mechanical Engineering and Applied Mechanics, University of Pennsylvania , 3231 Walnut Street, Philadelphia, PA 19104 ; , 3231 Walnut Street, Philadelphia, PA 19104 ; , 3231 Walnut Street, Philadelphia, PA 19104

10. Center for Engineering Mechanobiology, University of Pennsylvania , 3231 Walnut Street, Philadelphia, PA 19104 ; , 3231 Walnut Street, Philadelphia, PA 19104 ; , 3231 Walnut Street, Philadelphia, PA 19104

11. Department of Mechanical Engineering, School of Biomedical Engineering, Translational Medicine Institute, Colorado State University , 400 Isotope Drive, Fort Collins, CO 80521

12. Department of Biomedical Engineering, , University Park, PA 16802 ; , University Park, PA 16802

13. Pennsylvania State University , University Park, PA 16802 ; , University Park, PA 16802

14. Department of Orthopaedics and Rehabilitation, Pennsylvania State University , University Park, PA 16802 ; , University Park, PA 16802

Abstract

Abstract The 2021 Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) featured a workshop titled “The Elephant in the Room: Nuclear Mechanics and Mechanobiology.” The goal of this workshop was to provide a perspective from experts in the field on the current understanding of nuclear mechanics and its role in mechanobiology. This paper reviews the major themes and questions discussed during the workshop, including historical context on the initial methods of measuring the mechanical properties of the nucleus and classifying the primary structures dictating nuclear mechanics, physical plasticity of the nucleus, the emerging role of the linker of nucleoskeleton and cytoskeleton (LINC) complex in coupling the nucleus to the cytoplasm and driving the behavior of individual cells and multicellular assemblies, and the computational models currently in use to investigate the mechanisms of gene expression and cell signaling. Ongoing questions and controversies, along with promising future directions, are also discussed.

Funder

National Science Foundation

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Link

https://asmedigitalcollection.asme.org/biomechanical/article-pdf/144/8/080802/6863257/bio_144_08_080802.pdf

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