A Graphical Approach to Visualize and Interpret Biochemically Coupled Biomechanical Models

Author:

Flanary Shannon M.1,Peak Kara E.23,Barocas Victor H.2

Affiliation:

1. Department of Chemical Engineering & Materials Science, University of Minnesota, Nils Hasselmo Hall, Room 7-115, 312 Church St SE , Minneapolis, MN 55455

2. Department of Biomedical Engineering, University of Minnesota, Nils Hasselmo Hall, Room 7-115, 312 Church St SE , Minneapolis, MN 55455

3. University of Minnesota

Abstract

Abstract The last decade has seen the emergence of progressively more complex mechanobiological models, often coupling biochemical and biomechanical components. The complexity of these models makes interpretation difficult, and although computational tools can solve model equations, there is considerable potential value in a simple method to explore the interplay between different model components. Pump and system performance curves, long utilized in centrifugal pump selection and design, inspire the development of a graphical technique to depict visually the performance of biochemically-coupled mechanical models. Our approach is based on a biochemical performance curve (analogous to the classical pump curve) and a biomechanical performance curve (analogous to the system curve). Upon construction of the two curves, their intersection, or lack thereof, describes the coupled model's equilibrium state(s). One can also observe graphically how an applied perturbation shifts one or both curves, and thus how the other component will respond, without rerunning the full model. While the upfront cost of generating the performance curve graphic varies with the efficiency of the model components, the easily interpretable visual depiction of what would otherwise be nonintuitive model behavior is valuable. Herein, we outline how performance curves can be constructed and interpreted for biochemically-coupled biomechanical models and apply the technique to two independent models in the cardiovascular space. The performance curve approach can illustrate and help identify weaknesses in model construction, inform user-applied perturbations and fitting procedures to generate intended behaviors, and improve the efficiency of the model generation and application process.

Funder

National Heart, Lung, and Blood Institute

Publisher

ASME International

Reference31 articles.

1. A Structural Bio-Chemo-Mechanical Model for Vascular Smooth Muscle Cell Traction Force Microscopy;Biomech. Model. Mechanobiol.,2023

2. A Computational Bridge Between Traction Force Microscopy and Tissue Contraction;J. Appl. Phys.,2023

3. A Multiscale Model of Cardiac Concentric Hypertrophy Incorporating Both Mechanical and Hormonal Drivers of Growth;Biomech. Model. Mechanobiol.,2021

4. From Transcript to Tissue: Multiscale Modeling From Cell Signaling to Matrix Remodeling;Ann. Biomed. Eng.,2021

5. Multiscale Model of Heart Growth During Pregnancy: Integrating Mechanical and Hormonal Signaling;Biomech. Model. Mechanobiol.,2022

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3