Temperature Distributions During Thermoradiotherapy: A Sensitivity Study With a Transient Numerical Model of the Rabbit Eye

Author:

Tompkins D. T.1,Klein S. A.2,Steeves R. A.3

Affiliation:

1. Department of Engineering Experiment Station. University of Wisconsin—Madison, Madison, WI 53703

2. Department of Mechanical Engineering. University of Wisconsin—Madison, Madison, WI 53703

3. Department of Human Oncology. University of Wisconsin—Madison, Madison, WI 53703

Abstract

An approach to the treatment of medium-sized choroidal melanomas combines radiation with ferromagnetic hyperthermia. The study herein discusses results with a numerical thermal model of a choroidal melanoma in the rabbit eye as treated with episcleral, thermoradiotherapy plaques. The sensitivity of a temperature–dependent blood perfusion model is investigated.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Reference39 articles.

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2. Beyer, W. H., ed., CRC Standard Mathematical Tables, 26th ed., CRC Press, Boca Raton, FL, 1981, pp. 276.

3. Bowman, H. F., “Thermodynamics of tissue heating: modeling and measurements for temperature distributions,” in: Physical Aspects of Hyperthermia, Nussbaum, G. H., ed., American Institute of Physics, New York, 1982, pp. 511–548.

4. Burnett, D. S., Finite Element Analysis: From Concepts to Applications, Addison Wesley Publishing Co., Reading, MA, 1987, pp. 376–401.

5. Clarke A. M. , GeeraetsW. J., and HamW. T., “An equilibrium thermal model for retinal injury from optical sources,” Applied Optics, Vol. 8(5), 1969, pp. 1051–1054.

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