VASCULAR ARTERY SIMULATION MODEL FABRICATION FOR PRE-SURGERY KIT FOR STENT APPLICATION THROUGH 3D PRINTING
Author:
UĞURTAŞ Tuğba1ORCID, YILMAZER Hakan1ORCID
Affiliation:
1. YILDIZ TECHNICAL UNIVERSITY
Abstract
Thrombosis occurs of a blood clot in the vein and blocking blood flow. The formation of a clot within the artery is called arterial thrombosis. Due to arterial thrombosis, there are heart attacks and strokes that result in more than 17.9 million deaths worldwide each year. Covid-19, one of today's problems, further increases the mortality rate. The thrombosis mechanism includes factors coming from the blood and the vessel wall. This mechanism is based on local blood flow mechanisms and 3-dimensional (3D) vessel geometry. Microfluidics chip-based vascular models examine the interaction between blood and the vessel wall in vitro studies in thrombosis. Until now, the 3-dimensional geometry of the arteries and blood flow system of healthy or unhealthy individuals have not been fully modeled. In this study, a patient-specific occluded blood vessel model was obtained from computed tomography angiography (CTA) data, and miniature vascular structures were developed with a 3D printer. These structures were printed using Acrylonitrile Butadiene Styrene (ABS). 3D ABS samples were used in Polydimethylsiloxane (PDMS) based soft lithography molds to occur microfluidic systems containing miniaturized replicas of in vivo vessel geometries. A comprehensive simulation of stented vasculature was performed by flow analysis of artificial blood and cell culture by placing a commercial stent on PDMS-based models. This project has aimed to develop and characterize modules by creating microfluidic systems using 3D printers to examine the effects of stents placed in the patient's complex vascular system and to simulate operations before treatment and stent placement.
Funder
2209-A Üniversite Öğrencileri Araştırma Projeleri Desteği Programı TÜBİTAK
Publisher
International Journal of 3D Printing Technologies and Digital Industry
Subject
Marketing,Economics and Econometrics,General Materials Science,General Chemical Engineering
Reference25 articles.
1. 1. World Health Organization. “Cardiovascular Diseases (CVDs)”, https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds), June 11, 2021. 2. 2. Torres, I. and Luccia, N. de, “Artificial vascular models for endovascular training (3D printing)”, Innovative Surgical Sciences, Vol. 3, Issue 3, Pages 225–234, 2018. 3. 3. Jirouskova, M., Shet, A.S., & Johnson, G.J., “A guide to murine platelet structure, function, assays, and genetic alterations”, Journal of Thrombosis and Haemostasis, Vol. 5, Issue 4, Pages 661-669, 2007. 4. 4. Suo, J., Ferrara, D.E., Sorescu, D., Guldberg, R.E., Taylor, W.R., and Giddens, D.P. “Hemodynamic shear stresses in mouse aortas: implications for atherogenesis”, Arteriosclerosis, Thrombosis, And Vascular Biology, Vol. 27, Issue 2, Pages 346-351, 2007. 5. 5. Van Kruchten, R., Cosemans, J.M., and Heemskerk, J.W., “Measurement of whole blood thrombus formation using parallel-plate flow chambers–a practical guide”, Platelets, Vol. 23, Issue 3, Pages 229-242, 2012.
|
|