Evaluation of Lymphocyte Subgroups in Children with Subacute Sclerosing Panencephalitis

Author:

Yilmaz C1,Yuca SA2,Yilmaz N3,Öner AF2,Çaksen H2

Affiliation:

1. Department of Paediatric Neurology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey

2. Department of Paediatrics, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey

3. Department of Neurosurgery, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey

Abstract

The aetiology of subacute sclerosing panencephalitis (SSPE) remains to be fully elucidated, although it follows infection with a hypermutant defective M-protein measles virus. This study analysed peripheral blood lymphocyte subgroups to determine their role in the pathophysiology of SSPE. It included 22 children with SSPE aged 2-15 years (patient group) and 22 age- and gender-matched healthy children (control group). In children < 6 years old, there were no statistically significant differences between the two groups in the proportions of lymphocytes expressing the surface markers CD3, CD8, CD19 or CD16/56, or in CD4/CD8 ratio. The proportion of CD4+ lymphocytes in SSPE patients < 6 years of age was significantly lower compared with the control group. In children ≥ 6 years old, there were no significant differences in the lymphocyte subgroups. In conclusion, these findings suggest that a low CD4+ lymphocyte count might be responsible for SSPE in younger children.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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