Assessment of Protective Effects of Pheniramine Maleate on Reperfusion Injury in Lung After Distant Organ Ischemia-Reference-Cited by-同舟云学术

Assessment of Protective Effects of Pheniramine Maleate on Reperfusion Injury in Lung After Distant Organ Ischemia

Published:2013-01-31 Issue:3 Volume:47 Page:219-224
ISSN:1538-5744
Container-title:Vascular and Endovascular Surgery
language:en
Short-container-title:Vasc Endovascular Surg

Author:

Gokalp Orhan¹,Yurekli Ismail²,Kiray Muge³,Bagriyanik Alper⁴,Yetkin Ufuk²,Yurekli Banu Sarer⁵,Gur Serkan⁶,Aksun Murat⁷,Satoglu Ismail Safa⁸,Gokalp Gamze⁹,Gurbuz Ali¹

Affiliation:

1. Department of Cardiovascular Surgery, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey

2. Department of Cardiovascular Surgery, Izmir Ataturk Education and Research Hospital, Izmir, Turkey

3. Department of Physiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

4. Department of Histology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

5. Department of Endocrinology, Izmir Education and Research Hospital, Izmir, Turkey

6. Department of Radiology, Izmir Sifa Hospital, Izmir, Turkey

7. Department of Anesthesia and Reanimation, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey

8. Department of Orthopedics and Traumatology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey

9. Department of Pediatrics, DrHayri Ustundag Kadın Hastaliklari ve Dogum Hospital, Izmir, Turkey

Abstract

Objective: The aim of this study is to investigate the protective effects of methylprednisolone (MP) and pheniramine maleate (PM) on reperfusion injury of lungs developing after ischemia of the left lower extremity of rats. Materials and methods: A total of 28 randomly selected male rats were divided into 4 groups, each consisting of 7 rats. Group 1 was the control group. Group 2 was the sham group (ischemia/reperfusion [I/R]). Rats in group 3 were subjected to I/R and given PM (Ph group) and rats in group 4 were subjected to I/R and given MP (Pn group). Results: Malondialdehyde levels were significantly lower in Ph group than in I/R group ( P < .05). Superoxide dismutase and glutathione peroxidase enzyme activities were found to be significantly higher in Ph group than in the I/R group ( P < .05). Histological examination demonstrated that PM had protective effects against I/R injury. Conclusions: The PM has a protective effect against I/R injury in rat lung.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,General Medicine,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/1538574413475885

Reference19 articles.

1. The Pathophysiology of Skeletal Muscle Ischemia and the Reperfusion Syndrome: A Review

2. Effects of Methylprednisolone and Its Liver-Targeted Dextran Prodrug on Ischemia–Reperfusion Injury in a Rat Liver Transplantation Model

3. The acute cardioprotective effect of glucocorticoid in myocardial ischemia–reperfusion injury occurring during cardiopulmonary bypass

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Effect of pheniramine maleate on rat skeletal muscle ischemia-reperfusion injury;Turkish Journal of Trauma and Emergency Surgery;2022

2. Combined drugs in the treatment of acute respiratory viral infections: a review of research results;Meditsinskiy sovet = Medical Council;2021-04-20

The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats

;International Journal of Nanomedicine;2020-10

4. Direct kidney injury or lower extremity ischemia induced indirect kidney injury: Which one is more harmful for kidneys?;Vascular;2020-09-22

5. Which Distant Organ is Most Affected by Lower Extremity Ischemia-Reperfusion?;Annals of Vascular Surgery;2020-05