Hydroxyapatite gradient on poly (vinyl alcohol) hydrogels surface to mimic calcified cartilage zone for cartilage repair

Author:

Shi Lin1ORCID,Chen Jiongrun2,Tian Ye1,Ren Li2

Affiliation:

1. Guangdong Food and Drug Vocational College, Guangzhou, China

2. National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, China

Abstract

Poly (vinyl alcohol) (PVA) hydrogels are considered promising artificial articular cartilage. However, the weak attachment between PVA hydrogels and subchondral bone limit its application in the biomedical field. In this article, we present a new method to improve the mineralization of PVA hydrogels, and fabricate PVA hydrogels with continuously graded hydroxyapatite coating. The surface of the hydrogels was modified by dopamine self-polymerization and alendronate conjugation subsequently. Based on these, we used simulated body fluids to mineralize the hydrogels to mimic calcified cartilage zone. The modified surface of the PVA hydrogels showed excellent mineralization ability with continuously graded hydroxyapatite (HA). As the main component of human bones, HA can be chemically bonded body tissue on the interface, showing great biological activity. With the content of HA increasing, the cell adhesion ability of the hydrogels was enhanced, which helped the hydrogels integrate tightly with subchondral bone. These results demonstrate that the modified hydrogels could be promising substitutes for articular cartilage.

Funder

Characteristic Innovation Project of Guangdong Provincial Department of Education

Natural Science Research Project of GDYZY

Medical Science and Technology Research Fund of Guangdong Province

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials

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