International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery

Author:

Lindgren Arne G12ORCID,Braun Robynne G3,Juhl Majersik Jennifer4,Clatworthy Philip5,Mainali Shraddha6,Derdeyn Colin P7,Maguire Jane8,Jern Christina910,Rosand Jonathan11,Cole John W1213,Lee Jin-Moo14,Khatri Pooja15,Nyquist Paul16ORCID,Debette Stéphanie1718,Keat Wei Loo19,Rundek Tatjana20,Leifer Dana21,Thijs Vincent22ORCID,Lemmens Robin2324,Heitsch Laura14,Prasad Kameshwar25,Jimenez Conde Jordi2627,Dichgans Martin28,Rost Natalia S11,Cramer Steven C2930,Bernhardt Julie22ORCID,Worrall Bradford B31,Fernandez-Cadenas Israel32,

Affiliation:

1. Department of Clinical Sciences Lund, Neurology, -->Lund University, Lund, Sweden

2. Department of Neurology, Skåne University Hospital, Lund, Sweden

3. Department of Neurology, University of Maryland, Baltimore, MD, USA

4. Department of Neurology, University of Utah, Salt Lake City, UT, USA

5. Department of Neurology, North Bristol NHS Trust, Bristol, UK

6. Department of Neurology, -->The Ohio State University, Columbus, OH, USA

7. Department of Radiology, University of Iowa, Iowa City, IA, USA

8. Faculty of Health, University of Technology Sydney, Ultimo, NSW, Australia

9. Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden

10. Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden

11. Department of Neurology, Massachusetts General Hospital, Boston, MA, USA

12. Neurology Service, Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA

13. Department of Neurology, -->University of Maryland School of Medicine, Baltimore, MD, USA

14. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA

15. Department of Neurology and Rehabilitation Sciences, University of Cincinnati, Cincinnati, OH, USA

16. Neurology, Anesthesiology/Critical Care Medicine, Neurosurgery, and General Internal Medicine, -->Johns Hopkins School of Medicine, Baltimore, MD, USA

17. Bordeaux Population Health, Inserm U1219, University of Bordeaux, Bordeaux, France

18. Neurology Department, Bordeaux University Hospital, Bordeaux, France

19. Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak, Malaysia

20. Department of Neurology, -->University of Miami Miller School of Medicine, Miami, FL, USA

21. Department of Neurology, Weill Cornell Medicine, New York, NY, USA

22. Stroke Theme, Florey Institute of Neuroscience and Mental Health, Melbourne, Vic, Australia

23. Department of Neuroscience, University of Leuven, Leuven, Belgium

24. Department of Neurology, University Hospitals Leuven, Leuven, Belgium

25. Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India

26. Neurology Department, Neurovascular Research Group, Institut Hospital del Mar d’Investigació Mèdica, Barcelona, Spain

27. Neurology, Universitat Autònoma de Barcelona, Barcelona, Spain

28. Institute for Stroke and Dementia Research, University Hospital, LMU, Munich, Germany

29. Department of Neurology, UCLA, Los Angeles, CA, USA

30. California Rehabilitation Institute, Los Angeles, CA, USA

31. Department of Neurology, University of Virginia, Charlottesville, VA, USA

32. Stroke Pharmacogenomics and Genetics Group, Sant Pau Biomedical Research Institute, Barcelona, Spain

Abstract

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.

Funder

NIH/NICHD

Lunds Universitet

NIH-NINDS

NIH

Department of Biotechnology, Govt. of India

NIH/NINDS

Swedish Government

Skånes universitetssjukhus

US Department of Veterans Affairs, the AHA

Region Skåne

Fremasons Lodge of Instruction Eos in Lund

FWO Flanders

Sparbanksstiftelsen Fãrs och Frosta

The Swedish Heart and Lung Foundation

Vetenskapsrådet

Publisher

SAGE Publications

Subject

Neurology

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