Review: Functional Neuroimaging Studies of Early Upper Limb Recovery After Stroke: A Systematic Review of the Literature

Author:

Buma Floor E.1,Lindeman Eline2,Ramsey Nick F.2,Kwakkel Gert3

Affiliation:

1. University Medical Centre Utrecht, Utrecht, Netherlands,

2. University Medical Centre Utrecht, Utrecht, Netherlands

3. University Medical Centre Utrecht, Utrecht, Netherlands, VU University Medical Centre, Amsterdam, Netherlands

Abstract

Background. Understanding mechanisms of recovery may result in new treatment strategies to improve motor outcome after stroke. Imaging techniques such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) allow changes in brain activity after stroke recovery to be identified. Objective. To systematically review serial imaging studies on recovery within 6 months poststroke, assess their methodological quality, and identify trends in the association between task-related brain activation patterns and functional upper limb recovery. Methods. A literature search was performed using Medline, PICARTA, and EMBASE databases. Studies were appraised using binary weighted methodological criteria for internal, statistical, and external validity. Results. Twenty-two of the 869 identified studies met the inclusion criteria. Studies showed methodological weaknesses with respect to controlling for task performance, selecting appropriate outcome measures, and adequate presentation and execution of statistical analysis. After stroke, motor task performance shows unilateral overactivation of motor and nonmotor areas, a posterior shift in activity in the primary motor cortex, and bilateral recruitment of associated motor and nonmotor areas. Concomitant with neurological recovery, overactivation appears to diminish longitudinally, but not in all patients. Conclusion . Despite methodological shortcomings and heterogeneity, trends can be discerned. However, statistically sound associations with recovery are not consistent. The challenges in future research will be, controlling for confounding factors, finding outcomes that specifically measure dexterity of the paretic limb, to control for the extent of white matter damage and changes in perfusion in order to establish the longitudinal construct validity of fMRI and PET with regard to upper limb recovery after stroke.

Publisher

SAGE Publications

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3