A Clinicoepidemiological Study of Melanoma in Young Patients (20 Years of Age or Less) in Alberta, Canada, From 1992 to 2011

Author:

AlZahrani Fatmah1ORCID,Kuzel Paul1,Metelitsa Andrei23,Smylie Michael4,Dover Douglas5ORCID,Fiorillo Loretta1

Affiliation:

1. Division of Dermatology and Cutaneous Sciences, Department of Medicine, University of Alberta, Edmonton, Canada

2. Division of Dermatology, University of Calgary, Alberta, Canada

3. Department of Dermatology, Beacon Dermatology, Calgary, Alberta, Canada

4. Division of Medical Oncology, Department of Oncology, University of Alberta, Edmonton, Canada

5. Alberta Health and Wellness, Community and Population Health Division, Surveillance and Assessment, University of Alberta, Edmonton, Alberta, Canada

Abstract

The epidemiological trends of malignant melanoma have been well described in the literature. However, there remains a paucity of population-based studies assessing melanoma epidemiology in our younger patients (20 years of age or less). Other studies indicate that melanoma incidence has risen in pediatric populations over the last several decades and that these tumors may display different clinical characteristics from those arising in adult populations. We conducted a retrospective, population-based analysis of all incident cases of melanoma occurring in young patients aged ≤20 years in Alberta from 1992 to 2011. Information, including patient age, sex, anatomical location, date of diagnosis, histological subtype (if available), level of invasion, and date of death (if applicable), was obtained from the Alberta Cancer Registry. All cases occurring during a 10-year period from 1993 to 2011 have been reviewed. A total of 71 cases were diagnosed during this time (63% female and 37% male). Age range was 0-20 years (mean of 17.5 years). Truncal melanomas made up 36% of cases, while 28% occurred on the lower limbs, 17% on the upper limbs, and 18% in the head and neck region. Average Breslow thickness was 1.97 mm; 67% of tumors were less than 1 mm thick. Unfortunately, 8 of 71 patients died from their disease. Overall, the incidence of melanoma in patients aged ≤20 years appeared to decrease in Alberta in the past 20 years; however, there has been an increase in the thickness of melanoma at diagnosis, which needs to be addressed.

Publisher

SAGE Publications

Subject

Dermatology,Surgery

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Melanoma in children: A systematic review and individual patient meta‐analysis;Journal of the European Academy of Dermatology and Venereology;2023-06-02

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